Interleukin-23 drives innate and T cell-mediated intestinal inflammation (Q24677051)

1

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Philip Ahern

2

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Sofia Buonocore

3

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Marika C Kullberg

4

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Daniel J Cua

5

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Brent S McKenzie

6

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Kevin J Maloy

Journal of Experimental Medicine

8

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language of work or name

English

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publication date

30 October 2006

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published in

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volume

203

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issue

11

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page(s)

2473-83

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cites work

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28 September 2017

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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

28 September 2017

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Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells.

28 September 2017

1 reference

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

28 September 2017

1 reference

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Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

28 September 2017

1 reference

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

28 September 2017

1 reference

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Claudins regulate the intestinal barrier in response to immune mediators

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

Flow cytometric identification of murine neutrophils and monocytes.

30 May 2018

1 reference

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Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118132

Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

28 November 2018

1 reference

12 December 2020

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

1 reference

12 December 2020

Understanding the IL-23-IL-17 immune pathway

1 reference

12 December 2020

TGF-beta, a 'double agent' in the immune pathology war

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20061099

1 reference

1350971

1350971

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1 reference

1 reference