Interleukin-12 and the regulation of innate resistance and adaptive immunity (Q29614602)

Europe PubMed Central

title

Interleukin-12 and the regulation of innate resistance and adaptive immunity (English)

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30 April 2017

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Trinchieri G

1

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30 April 2017

language of work or name

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30 April 2017

publication date

February 2003

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Nature Reviews Immunology

30 April 2017

published in

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volume

3

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page(s)

133-46

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issue

2

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The immune system evolved to discriminate infectious nonself from noninfectious self

30 April 2017

cites work

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A family of human receptors structurally related to Drosophila Toll

31 March 2020

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Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens

31 March 2020

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Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors

31 March 2020

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Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells

31 March 2020

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Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells.

31 March 2020

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

31 March 2020

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Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

31 March 2020

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

31 March 2020

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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

31 March 2020

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

31 March 2020

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Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

31 March 2020

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Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

31 March 2020

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31 March 2020

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

31 March 2020

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

31 March 2020

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A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

31 March 2020

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

31 March 2020

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

31 March 2020

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IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

31 March 2020

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Selective expression of an interleukin-12 receptor component by human T helper 1 cells

31 March 2020

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Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

31 March 2020

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Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.

31 March 2020

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Biosynthesis and posttranslational regulation of human IL-12.

31 March 2020

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Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

31 March 2020

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In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas

31 March 2020

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CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal

31 March 2020

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Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo

31 March 2020

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Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter.

31 March 2020

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CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells

31 March 2020

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c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

31 March 2020

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Regulation of interleukin-12 production in antigen-presenting cells

31 March 2020

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Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

31 March 2020

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Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

31 March 2020

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

31 March 2020

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Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production

31 March 2020

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

31 March 2020

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IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic Cells

31 March 2020

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Differential response of the murine IL-12 p35 gene to lipopolysaccharide compared with interferon-gamma and CD40 ligation

31 March 2020

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Reciprocal activating interaction between natural killer cells and dendritic cells

31 March 2020

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Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

31 March 2020

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In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting

31 March 2020

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The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

31 March 2020

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Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells.

31 March 2020

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Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection

31 March 2020

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Regulation of interleukin-12 production by G-protein-coupled receptors

31 March 2020

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Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production

31 March 2020

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Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

31 March 2020

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Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.

31 March 2020

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Disparate intracellular processing of human IL-12 preprotein subunits: atypical processing of the P35 signal peptide

31 March 2020

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Interleukin-12: a cytokine at the interface of inflammation and immunity

31 March 2020

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Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present

31 March 2020

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Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

31 March 2020

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Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

31 March 2020

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B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

31 March 2020

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Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

31 March 2020

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Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-2 represents a novel form of posttranscriptional control

31 March 2020

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Interleukin-18: a novel cytokine that augments both innate and acquired immunity

31 March 2020

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A newly defined interleukin-1?

31 March 2020

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Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.

31 March 2020

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The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit.

31 March 2020

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Interleukin-18 regulates both Th1 and Th2 responses

31 March 2020

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Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation

31 March 2020

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Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells

31 March 2020

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IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells

31 March 2020

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CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells

31 March 2020

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Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells

31 March 2020

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The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

31 March 2020

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Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

31 March 2020

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Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

31 March 2020

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Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

31 March 2020

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Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

31 March 2020

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Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells.

31 March 2020

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Development of Th1-type immune responses requires the type I cytokine receptor TCCR

31 March 2020

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A novel transcription factor, T-bet, directs Th1 lineage commitment

31 March 2020

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

31 March 2020

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Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.

31 March 2020

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

31 March 2020

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

31 March 2020

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

31 March 2020

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

31 March 2020

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Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

31 March 2020

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Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts

31 March 2020

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An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease

31 March 2020

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The plasticity of dendritic cell responses to pathogens and their components

31 March 2020

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Regulation of interleukin 12 p40 expression through an NF-kappa B half-site

31 March 2020

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Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins

31 March 2020

1 reference

Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2).

31 March 2020

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C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages.

31 March 2020

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Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.

31 March 2020

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Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation

31 March 2020

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An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages

31 March 2020

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Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

31 March 2020

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Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin-12 transcription by regulating nuclear factor kappaB and Ets activation

31 March 2020

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Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii

31 March 2020

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IL-12 is required to maintain a Th1 response during Leishmania major infection.

31 March 2020

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Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration

31 March 2020

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Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection

31 March 2020

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Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.

31 March 2020

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Differential tumor surveillance by natural killer (NK) and NKT cells.

31 March 2020

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Antitumor and antimetastatic activity of interleukin 12 against murine tumors

31 March 2020

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Effect of interleukin 12 on tumor induction by 3-methylcholanthrene

31 March 2020

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Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice

31 March 2020

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Interleukin-12 in anti-tumor immunity and immunotherapy.

31 March 2020

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Inhibition of angiogenesis in vivo by interleukin 12.

31 March 2020

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Immunological prevention of spontaneous tumors: a new prospect?

31 March 2020

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Gp130 and the interleukin-6 family of cytokines

31 March 2020

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Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit

31 March 2020

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A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Local immune responses to Chlamydia pneumoniae in the lungs of BALB/c mice during primary infection and reinfection

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inferred from DOI database lookup

7 January 2021

based on heuristic

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