Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. (Q24678783)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17956977%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

title

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice (English)

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9 January 2020

1

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9 January 2020

S C Richardson

5

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9 January 2020

Robert C. Piper

6

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9 January 2020

Sean J. Morrison

10

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9 January 2020

author name string

Sergey N Zolov

2

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9 January 2020

Clement Y Chow

3

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9 January 2020

Shalom G Slutsky

4

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9 January 2020

Baoli Yang

7

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9 January 2020

Johnathan J Nau

8

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9 January 2020

Randal J Westrick

9

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9 January 2020

Miriam H Meisler

11

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9 January 2020

Lois S Weisman

12

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9 January 2020

language of work or name

English

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publication date

23 October 2007

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Proceedings of the National Academy of Sciences of the United States of America

9 January 2020

published in

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9 January 2020

volume

104

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9 January 2020

page(s)

17518-17523

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9 January 2020

issue

44

1 reference

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

9 January 2020

cites work

1 reference

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Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif

7 April 2017

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A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy

7 April 2017

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The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

7 April 2017

1 reference

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Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors

7 April 2017

1 reference

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The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans

7 April 2017

1 reference

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The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

7 April 2017

1 reference

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Mutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophy

7 April 2017

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A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity

7 April 2017

1 reference

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PIKfyve Controls Fluid Phase Endocytosis but Not Recycling/Degradation of Endocytosed Receptors or Sorting of Procathepsin D by Regulating Multivesicular Body Morphogenesis

7 April 2017

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Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases

7 April 2017

1 reference

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Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

7 April 2017

1 reference

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Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity

7 April 2017

1 reference

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Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications

7 April 2017

1 reference

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Vacuole Size Control: Regulation of PtdIns(3,5)P2Levels by the Vacuole-associated Vac14-Fig4 Complex, a PtdIns(3,5)P2-specific Phosphatase

7 April 2017

1 reference

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Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body

7 April 2017

1 reference

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Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

7 April 2017

1 reference

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A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

7 April 2017

1 reference

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Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

7 April 2017

1 reference

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Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

7 April 2017

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Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells

7 April 2017

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Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve

7 April 2017

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Essential role of phosphoinositide metabolism in synaptic vesicle recycling

7 April 2017

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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

7 April 2017

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Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases

7 April 2017

1 reference

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Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate

7 April 2017

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Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body

7 April 2017

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Retrograde transport from endosomes to the trans-Golgi network

7 April 2017

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Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels

7 April 2017

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Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes

28 September 2017

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Model-guided microarray implicates the retromer complex in Alzheimer's disease

28 September 2017

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An animal model for Charcot-Marie-Tooth disease type 4B1.

28 September 2017

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Structure and function of the Lowe syndrome protein OCRL1.

28 September 2017

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Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis

28 September 2017

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Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

28 September 2017

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Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

28 September 2017

1 reference

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Phosphoinositide signaling disorders in human diseases

28 September 2017

1 reference

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Creating new fluorescent probes for cell biology.

28 September 2017

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Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity

28 September 2017

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Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2.

28 September 2017

1 reference

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Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

28 September 2017

1 reference

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Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts

28 September 2017

1 reference

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Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2077288

PtdIns(3,5)P2 is required for delivery of endocytic cargo into the multivesicular body.

28 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0702275104

A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0702275104

21 January 2018

Identifiers

DOI

10.1073/PNAS.0702275104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17956977%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

9 January 2020

ADS bibcode

2007PNAS..10417518Z

0 references

5087260

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

5087260

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17956977%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference