Cdk5 regulates the organization of Nestin and its association with p35 (Q24679689)

2

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Samuli Vaittinen

3

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Hanna-Mari Pallari

4

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Hannu Kalimo

5

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Harish C Pant

6

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John E Eriksson

Molecular and Cellular Biology

7

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language of work or name

English

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publication date

July 2003

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published in

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volume

23

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issue

14

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page(s)

5090-106

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cites work

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Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase

7 April 2017

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Neurotoxicity induces cleavage of p35 to p25 by calpain

7 April 2017

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Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain

7 April 2017

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p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

7 April 2017

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

7 April 2017

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A high molecular weight intermediate filament-associated protein in BHK-21 cells is nestin, a type VI intermediate filament protein. Limited co-assembly in vitro to form heteropolymers with type III vimentin and type IV alpha-internexin

7 April 2017

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The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase

7 April 2017

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Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells

7 April 2017

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

7 April 2017

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

7 April 2017

1 reference

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Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

7 April 2017

1 reference

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

7 April 2017

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

7 April 2017

1 reference

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CNS stem cells express a new class of intermediate filament protein

7 April 2017

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Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle

7 April 2017

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7 April 2017

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Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament metabolism

28 September 2017

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Keratins turn over by ubiquitination in a phosphorylation-modulated fashion

28 September 2017

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Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

28 September 2017

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Intermediate filaments and their associates: multi-talented structural elements specifying cytoarchitecture and cytodynamics

28 September 2017

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A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice

28 September 2017

1 reference

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Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclin-dependent kinase 5: structural basis for substrate recognition

28 September 2017

1 reference

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Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Colocalization of nestin and vimentin/desmin in skeletal muscle cells demonstrated by three-dimensional fluorescence digital imaging microscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Myogenesis and the intermediate filament protein, nestin.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Specific and innervation-regulated expression of the intermediate filament protein nestin at neuromuscular and myotendinous junctions in skeletal muscle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Transient expression of the intermediate filament nestin during skeletal muscle development.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Induction of Cdk5 activity in rat skeletal muscle after nerve injury

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Neurofilaments are part of the high molecular weight complex containing neuronal cdc2-like kinase (nclk).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation by tau protein kinase II.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=162223

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12832492

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The expression of intermediate filament protein nestin as related to vimentin and desmin in regenerating skeletal muscle

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12832492