Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration (Q28140796)

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L Zukerberg

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M Nikolic

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S de la Monte

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P Dikkes

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L H Tsai

A family of human cdc2-related protein kinases

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language of work or name

English

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publication date

9 December 1999

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published in

Nature

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volume

402

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page(s)

615-22

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issue

6762

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cites work

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling

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