Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway (Q24681629)

2

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Vilma Graupner

3

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Lilian Stärck

4

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Silke Radetzki

5

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Bernd Dörken

6

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Klaus Schulze-Osthoff

7

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Peter T Daniel

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

8

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language of work or name

English

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publication date

15 July 2003

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published in

The EMBO Journal

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volume

22

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issue

14

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page(s)

3580-90

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cites work

1 reference

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

7 April 2017

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

7 April 2017

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Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

7 April 2017

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

7 April 2017

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

7 April 2017

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Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

7 April 2017

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BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria

7 April 2017

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

7 April 2017

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

7 April 2017

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Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins

7 April 2017

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

7 April 2017

1 reference

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Bax directly induces release of cytochrome c from isolated mitochondria

7 April 2017

1 reference

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Guardians of cell death: the Bcl-2 family proteins

7 April 2017

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Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

28 September 2017

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

28 September 2017

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Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.

28 September 2017

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Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.

28 September 2017

1 reference

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

28 September 2017

1 reference

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The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

28 September 2017

1 reference

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Breaking the mitochondrial barrier

28 September 2017

1 reference

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

BH3-Only proteins-essential initiators of apoptotic cell death

28 September 2017

1 reference

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Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Role of BAX in the apoptotic response to anticancer agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Expression of the death gene Bik/Nbk promotes sensitivity to drug-induced apoptosis in corticosteroid-resistant T-cell lymphoma and prevents tumor growth in severe combined immunodeficient mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

28 September 2017

1 reference

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Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=165613

Characterization of tBid-induced cytochrome c release from mitochondria and liposomes.

30 May 2018

1 reference

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BID-dependent and BID-independent pathways for BAX insertion into mitochondria

28 November 2018

1 reference

12 December 2020

The pro-apoptotic protein, Bik, exhibits potent antitumor activity that is dependent on its BH3 domain

1 reference

12 December 2020

On negative selection against ATG triplets near start codons in eukaryotic and prokaryotic genomes

1 reference

12 December 2020

Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax.

1 reference

12 December 2020