Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB (Q24682284)

2

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Cintyu Wong

3

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Catherine L Drennan

4

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John M Essigmann

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

16 January 2007

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published in

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volume

104

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issue

3

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page(s)

755-60

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cites work

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Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

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Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

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AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo

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Repair of methylation damage in DNA and RNA by mammalian AlkB homologues

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Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

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Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

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AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

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The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein

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Probing the active site tightness of DNA polymerase in subangstrom increments

28 September 2017

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Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins

28 September 2017

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Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins

28 September 2017

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Alkylation damage in DNA and RNA--repair mechanisms and medical significance

28 September 2017

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Chloroethylnitrosourea-derived ethano cytosine and adenine adducts are substrates for Escherichia coli glycosylases excising analogous etheno adducts

28 September 2017

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Substrate specificities of bacterial and human AlkB proteins

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Repairing DNA-methylation damage

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Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase

28 September 2017

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AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism.

28 September 2017

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Reversal of DNA alkylation damage by two human dioxygenases

28 September 2017

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Recent progress on the Ada response for inducible repair of DNA alkylation damage

28 September 2017

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Structural insights by molecular dynamics simulations into differential repair efficiency for ethano-A versus etheno-A adducts by the human alkylpurine-DNA N-glycosylase

28 September 2017

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Genotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).

28 September 2017

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Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes

28 September 2017

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DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds

28 September 2017

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DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal

28 September 2017

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Metabolism of the chloroethylnitrosoureas

28 September 2017

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DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics

28 September 2017

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Synthesis of para-benzoquinone and 1,3-bis(2-chloroethyl)nitrosourea adducts and their incorporation into oligonucleotides

30 May 2018

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Formation of cyclic adducts in nucleic acids by the haloethylnitrosoureas

30 May 2018

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Nature and biological significance of DNA modification by the haloethylnitrosoureas

30 May 2018

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In vivo hprt mutant frequencies in T-cells of normal human newborns

30 May 2018

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Miscoding properties of 1,N6-ethanoadenine, a DNA adduct derived from reaction with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea

21 January 2018

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Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases

21 January 2018

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AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation

21 January 2018

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Assays for determining lesion bypass efficiency and mutagenicity of site-specific DNA lesions in vivo.

21 January 2018

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Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

21 January 2018

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The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

28 November 2018

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