Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance (Q24682390)

3

1 reference

ORCID Public Data File 2021

author name string

Jodie L Babitt

1

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Franklin W Huang

2

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Yisrael Sidis

4

0 references

Herbert Y Lin

Journal of Clinical Investigation

6

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language of work or name

English

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publication date

July 2007

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published in

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volume

117

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issue

7

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page(s)

1933-9

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cites work

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Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

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Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

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Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

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DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties

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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

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Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

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Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

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RGM is a repulsive guidance molecule for retinal axons

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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

7 April 2017

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

7 April 2017

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Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys

7 April 2017

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Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1

7 April 2017

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Balancing acts: molecular control of mammalian iron metabolism

7 April 2017

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

7 April 2017

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

7 April 2017

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Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

7 April 2017

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28 September 2017

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28 September 2017

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Regulation of hepcidin transcription by interleukin-1 and interleukin-6.

28 September 2017

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Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

28 September 2017

1 reference

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Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

28 September 2017

1 reference

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What do BMPs do in mammals? Clues from the mouse short-ear mutation

28 September 2017

1 reference

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STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

28 September 2017

1 reference

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Hepcidin is decreased in TFR2 hemochromatosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904317

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904317

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904317

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904317

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1904317

Decreased liver hepcidin expression in the Hfe knockout mouse

28 November 2018

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12 December 2020

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

1 reference

12 December 2020

Transforming growth factor-beta gene expression in normal and fibrotic rat liver

1 reference

12 December 2020

Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein

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12 December 2020

Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron

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12 December 2020

Hereditary hemochromatosis

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI31342

1 reference

464090

464090

1 reference

1 reference

1 reference