Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice (Q24682900)

Inosine monophosphate dehydrogenase 1

GOA release 2020-03-11

1 reference

Hypoxanthine guanine phosphoribosyl transferase

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Jing Jin Gu

1

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Amy K Tolin

2

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Jugnu Jain

3

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Hai Huang

4

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Lalaine Santiago

5

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Beverly S Mitchell

Molecular and Cellular Biology

6

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language of work or name

English

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publication date

September 2003

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published in

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volume

23

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issue

18

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page(s)

6702-12

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cites work

Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene

1 reference

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

7 April 2017

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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

7 April 2017

1 reference

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Two distinct cDNAs for human IMP dehydrogenase

7 April 2017

1 reference

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Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding

7 April 2017

1 reference

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Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs

7 April 2017

1 reference

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Characterization of human type I and type II IMP dehydrogenases

7 April 2017

1 reference

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VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent

7 April 2017

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The molecular basis of T helper 1 and T helper 2 cell differentiation

28 September 2017

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T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation

28 September 2017

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Mycophenolate mofetil: therapeutic applications in kidney transplantation and immune-mediated renal disease

28 September 2017

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Tissue-differential expression of two distinct genes for human IMP dehydrogenase (E.C.1.1.1.205).

28 September 2017

1 reference

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Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine

28 September 2017

1 reference

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Regulation of IMP dehydrogenase gene expression by its end products, guanine nucleotides

28 September 2017

1 reference

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Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines

28 September 2017

1 reference

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IMP dehydrogenase, an enzyme linked with proliferation and malignancy

28 September 2017

1 reference

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T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck

28 September 2017

1 reference

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De novo guanylate synthesis in the commitment to replication in hepatoma 3924A cells.

28 September 2017

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Lymphocyte-Selective Cytostatic and Immunosuppressive Effects of Mycophenolic Acid in Vitro: Role of Deoxyguanosine Nucleotide Depletion

30 May 2018

1 reference

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Inosine-5'-monophosphate dehydrogenase: regulation of expression and role in cellular proliferation and T lymphocyte activation.

30 May 2018

1 reference

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A mutational analysis of the active site of human type II inosine 5'-monophosphate dehydrogenase

19 June 2018

1 reference

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Mycophenolate mofetil treatment accelerates recovery from experimental allergic encephalomyelitis.

28 November 2018

1 reference

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Mycophenolate mofetil reduces production of interferon-dependent major histocompatibility complex induction during allograft rejection, probably by limiting clonal expansion

28 November 2018

1 reference

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Regulation of the human inosine monophosphate dehydrogenase type I gene. Utilization of alternative promoters

28 November 2018

1 reference

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A new triple-drug induction therapy with low dose cyclosporine, mizoribine and prednisolone in renal transplantation

28 November 2018

1 reference

12 December 2020

Advantages of mizoribine over azathioprine in combination therapy with cyclosporine for renal transplantation

1 reference

12 December 2020

Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism

1 reference

12 December 2020

Effects of human T lymphocyte activation on inosine monophosphate dehydrogenase expression

1 reference

12 December 2020

Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene

1 reference

12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

12 December 2020

CD28 costimulation promotes the production of Th2 cytokines

1 reference

12 December 2020

Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes

1 reference

12 December 2020

Networking Rho family GTPases in lymphocytes

1 reference

12 December 2020

A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on CD28 signaling and preferential inhibition of IL-10 production

1 reference

12 December 2020

TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway

1 reference

12 December 2020

CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation

1 reference

12 December 2020

10.1128/MCB.23.18.6702-6712.2003

Identifiers

DOI

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PubMed publication ID

12944494

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