Current developments in adenovirus-based cancer gene therapy (Q24683229)

The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction

Europe PubMed Central

title

Current developments in adenovirus-based cancer gene therapy (English)

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David T Curiel

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author name string

Daniel T Rein

series ordinal

1

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M Breidenbach

series ordinal

2

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language of work or name

English

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publication date

February 2006

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published in

Future Oncology

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volume

2

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issue

1

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page(s)

137-43

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cites work

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From molecular changes to customised therapy

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Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions

28 September 2017

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The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer: a functional analysis of car protein structure.

28 September 2017

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The role of chemoattraction in cancer metastases

28 September 2017

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Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes

28 September 2017

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28 September 2017

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Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells

28 September 2017

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28 September 2017

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Heparan sulfate proteoglycans in invasion and metastasis

28 September 2017

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Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial.

28 September 2017

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Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer

28 September 2017

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Dependence of adenovirus infectivity on length of the fiber shaft domain

28 September 2017

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

28 September 2017

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Osteocalcin-directed gene therapy for prostate-cancer bone metastasis

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism

28 September 2017

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Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob

28 September 2017

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Bacterial pneumonia causes augmented expression of the secretory leukoprotease inhibitor gene in the murine lung

28 September 2017

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

28 September 2017

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Quantitatively determined survivin expression levels are of prognostic value in human gliomas

28 September 2017

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Cross-species comparison of angiogenesis during the premalignant stages of squamous carcinogenesis in the human cervix and K14-HPV16 transgenic mice.

30 May 2018

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Addition of a short peptide ligand to the adenovirus fiber protein.

30 May 2018

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Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates

30 May 2018

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Gene transfer to cervical cancer with fiber-modified adenoviruses

21 January 2018

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Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells

21 January 2018

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Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

21 January 2018

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Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types

21 January 2018

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Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency

21 January 2018

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Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets

21 January 2018

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CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

21 January 2018

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A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

21 January 2018

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In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus

21 January 2018

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An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression

21 January 2018

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

21 January 2018

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Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer

21 January 2018

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Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasia, and invasive squamous cell carcinoma

21 January 2018

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Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial

21 January 2018

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Phase II Trial of Intravenous CI-1042 in Patients With Metastatic Colorectal Cancer

21 January 2018

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Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate canc

21 January 2018

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A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma

28 November 2018

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Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints

28 November 2018

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Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix.

28 November 2018

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Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.

28 November 2018

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A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging.

28 November 2018

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Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer

28 November 2018

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An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

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12 December 2020

Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner

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12 December 2020

Expression of survivin and matrix metalloproteinases in adenocarcinoma and squamous cell carcinoma of the uterine cervix

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12 December 2020

Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells

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12 December 2020

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

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12 December 2020