A global role for EKLF in definitive and primitive erythropoiesis (Q24685702)

7

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Sean Grimmond

object named as

Sean Grimmond

8

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author name string

Denise Hodge

1

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Elise Coghill

2

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Janelle Keys

3

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Tina Maguire

4

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Belinda Hartmann

5

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Alasdair McDowall

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo

6

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language of work or name

English

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publication date

15 April 2006

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published in

Blood

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volume

107

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page(s)

3359-70

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issue

8

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cites work

1 reference

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C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF

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An abundant erythroid protein that stabilizes free alpha-haemoglobin

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Headpiece domain of dematin is required for the stability of the erythrocyte membrane

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A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

7 April 2017

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Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region

7 April 2017

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Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells

7 April 2017

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The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins

7 April 2017

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A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins

7 April 2017

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Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein

7 April 2017

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The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site

7 April 2017

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Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia

7 April 2017

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7 April 2017

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Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms

7 April 2017

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Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene

7 April 2017

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Mammalian Krüppel-like transcription factors: more than just a pretty finger

7 April 2017

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Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

7 April 2017

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Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

7 April 2017

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Cis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase gene

7 April 2017

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The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability

7 April 2017

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Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein

7 April 2017

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Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload

7 April 2017

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A mouse model for beta 0-thalassemia

7 April 2017

1 reference

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Rh proteins: key structural and functional components of the red cell membrane

7 April 2017

1 reference

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Mulan: multiple-sequence local alignment and visualization for studying function and evolution

28 September 2017

1 reference

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rVISTA 2.0: evolutionary analysis of transcription factor binding sites

28 September 2017

1 reference

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Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.

28 September 2017

1 reference

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Scianna antigens including Rd are expressed by ERMAP.

28 September 2017

1 reference

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Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

28 September 2017

1 reference

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Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway.

28 September 2017

1 reference

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Transcription factor erythroid Krüppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation

28 September 2017

1 reference

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Integrin-associated protein (IAP, also termed CD47) is involved in stroma-supported erythropoiesis

28 September 2017

1 reference

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Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Enhancement of coproporphyrinogen III transport into isolated transformed leukocyte mitochondria by ATP.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Erythroid regulatory elements

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

DNA sequences involved in transcriptional regulation of the mouse beta-globin promoter in murine erythroleukemia cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Structure and transcription of the mouse erythropoietin receptor gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Functional interaction of GATA1 with erythroid Krüppel-like factor and Sp1 at defined erythroid promoters.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Role of erythroid Kruppel-like factor in human gamma- to beta-globin gene switching

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

The role of EKLF in human beta-globin gene competition.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

DNA-binding specificity of GATA family transcription factors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Genetic and biochemical analysis of the mouse beta-major globin promoter

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

cDNA sequence, genomic structure, and expression of the mouse dematin gene (Epb4.9).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

X-linked sideroblastic anaemia due to a mutation in the erythroid 5-aminolaevulinate synthase gene leading to an arginine170 to leucine substitution.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

The human erythroid-specific transcription factor EKLF localizes to chromosome 19p13.12-p13.13.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895762

Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene. Identification of promoter elements and role of regulatory proteins

28 November 2018

1 reference

12 December 2020

Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

1 reference

12 December 2020

Fine structure genetic analysis of a beta-globin promoter

1 reference

12 December 2020

Structure of the 5′ flanking region of the gene encoding human glycophorin A and analysis of its multiple transcripts

1 reference

12 December 2020

Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter

1 reference

12 December 2020

Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor

1 reference

12 December 2020

10.1182/BLOOD-2005-07-2888

Identifiers

DOI

1 reference

1153520

1153520

1 reference

1 reference

1 reference