Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality (Q24745996)

2

Melinda C Aldrich

0 references

Joshua C. Denny

17

Joshua C Denny

0 references

Hua Xu

1

Hua Xu

0 references

Dan Roden

16

Dan M Roden

0 references

Qingxia Chen

3

Qingxia Chen

0 references

Mia A Levy

7

Mia Levy

0 references

Jeremy L. Warner

14

Jeremy Warner

0 references

author name string

Hongfang Liu

4

0 references

Neeraja B Peterson

5

0 references

Qi Dai

6

0 references

Anushi Shah

8

0 references

Xue Han

9

0 references

Xiaoyang Ruan

10

0 references

Min Jiang

11

0 references

Ying Li

12

0 references

Jamii St Julien

Journal of the American Medical Informatics Association

13

0 references

language of work or name

English

0 references

publication date

January 2015

0 references

published in

0 references

volume

22

0 references

page(s)

179-91

0 references

issue

1

0 references

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

electronic health records

1 reference

Data-driven prediction of drug effects and interactions

inferred from title

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin in cancer: translational challenges

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin and the risk of cancer: time-related biases in observational studies

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Rapalogs and mTOR inhibitors as anti-aging therapeutics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Drug target identification using side-effect similarity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin and reduced risk of cancer in diabetic patients

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Drug repositioning: identifying and developing new uses for existing drugs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Pharmacovigilance Using Clinical Notes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Association between metformin therapy and mortality after breast cancer: a population-based study

25 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Computational drug repositioning: from data to therapeutics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

A study of transportability of an existing smoking status detection module across institutions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Chapter 13: Mining electronic health records in the genomics era.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Drug repositioning by structure-based virtual screening

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Large-scale prediction and testing of drug activity on side-effect targets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Detection of pharmacovigilance-related adverse events using electronic health records and automated methods

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin use is associated with better survival of diabetic patients with pancreatic cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Extracting and integrating data from entire electronic health records for detecting colorectal cancer cases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Predicting clopidogrel response using DNA samples linked to an electronic health record.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Automated identification of postoperative complications within an electronic medical record using natural language processing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Discovery and preclinical validation of drug indications using compendia of public gene expression data

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Reengineering translational science: the time is right

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Literature mining, ontologies and information visualization for drug repurposing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

A study of machine-learning-based approaches to extract clinical entities and their assertions from discharge summaries.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Electronic medical records for genetic research: results of the eMERGE consortium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Diabetes mellitus, fasting glucose, and risk of cause-specific death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Multiple imputation using chained equations: Issues and guidance for practice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Integrating existing natural language processing tools for medication extraction from discharge summaries.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin: taking away the candy for cancer?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Biobanking and pharmacogenomics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

MedEx: a medication information extraction system for clinical narratives.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

The value of drug repositioning in the current pharmaceutical market

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Use of electronic health records in U.S. hospitals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Extracting information from textual documents in the electronic health record: a review of recent research.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Development of a large-scale de-identified DNA biobank to enable personalized medicine.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Finding new tricks for old drugs: an efficient route for public-sector drug discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

NIH Molecular Libraries Initiative

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Trends in development and approval times for new therapeutics in the United States

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Rational drug repositioning by medical genetics.

30 May 2018

1 reference

https://api.crossref.org/works/10.1136%2FAMIAJNL-2014-002649

Comparison of natural language processing biosurveillance methods for identifying influenza from encounter notes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FAMIAJNL-2014-002649

An electronic practice-based network for observational comparative effectiveness research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FAMIAJNL-2014-002649

Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FAMIAJNL-2014-002649

Accelerating the Use of Electronic Health Records in Physician Practices

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FAMIAJNL-2014-002649

Use of genome-wide association studies for drug repositioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FAMIAJNL-2014-002649

Mayo clinic smoking status classification system: extensions and improvements.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4433365

Diabetes and Cancer: A Consensus Report

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25053577

12 December 2020

inferred from PubMed ID database lookup

Signatures for drug repositioning

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25053577

12 December 2020

inferred from PubMed ID database lookup

Four-dollar generics--increased accessibility, impaired quality assurance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25053577

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1136/AMIAJNL-2014-002649

1 reference

journals/jamia/XuACLPDLSXRJLJW15

750079

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

750079

1 reference

1 reference

1 reference