Computational drug repositioning: from data to therapeutics (Q30594820)

25 June 2017

Computational drug repositioning: from data to therapeutics (English)

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25 June 2017

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6

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25 June 2017

M R Hurle

1

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25 June 2017

L Yang

2

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25 June 2017

Q Xie

3

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25 June 2017

D K Rajpal

4

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25 June 2017

P Sanseau

5

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25 June 2017

language of work or name

English

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publication date

15 January 2013

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Clinical Pharmacology & Therapeutics

25 June 2017

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25 June 2017

93

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25 June 2017

4

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25 June 2017

335-341

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Computational tools for polypharmacology and repurposing

25 June 2017

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

How were new medicines discovered?

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Drug repositioning: identifying and developing new uses for existing drugs

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

21 January 2018

New uses for old drugs

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Exploiting drug-disease relationships for computational drug repositioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Applications of Connectivity Map in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Human disease-drug network based on genomic expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Discovery and preclinical validation of drug indications using compendia of public gene expression data

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Identification of small molecules enhancing autophagic function from drug network analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Drug target identification using side-effect similarity

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Recycling side-effects into clinical markers for drug repositioning

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Systematic drug repositioning based on clinical side-effects

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

The impact of next-generation sequencing technology on genetics

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Exome sequencing as a tool for Mendelian disease gene discovery

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

NT5E mutations and arterial calcifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Creation and implications of a phenome-genome network

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

A pathway-based view of human diseases and disease relationships

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Mining small-molecule screens to repurpose drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

A conditional knockout resource for the genome-wide study of mouse gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Systematic evaluation of drug-disease relationships to identify leads for novel drug uses

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

PREDICT: a method for inferring novel drug indications with application to personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

PubChem's BioAssay Database

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Predicting adverse drug reactions using publicly available PubChem BioAssay data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Relating protein pharmacology by ligand chemistry

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Predicting new molecular targets for known drugs

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Docking and scoring in virtual screening for drug discovery: methods and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

21 January 2018

Mouse phenome database

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

GlaxoSmithKline grants researchers access to clinical trial data

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Mining electronic health records: towards better research applications and clinical care

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Identifying potential adverse effects using the web: a new approach to medical hypothesis generation

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Novel data-mining methodologies for adverse drug event discovery and analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Data-driven prediction of drug effects and interactions

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Open innovation for phenotypic drug discovery: The PD2 assay panel

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Translational bioinformatics: coming of age

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Translational bioinformatics: linking the molecular world to the clinical world

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Use of genome-wide association studies for drug repositioning

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

Capturing the unexpected benefits of medical research

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

Fish oil, Raynaud's syndrome, and undiscovered public knowledge

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

Editorial: computational methods for drug repurposing

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

A quantitative analysis of adverse events and "overwarning" in drug labeling

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

Large-scale prediction and testing of drug activity on side-effect targets

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

NCATS launches drug repurposing program

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

Drug research and translational bioinformatics

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https://api.crossref.org/works/10.1038%2FCLPT.2013.1

7 January 2021

Identifiers

DOI

10.1038/CLPT.2013.1

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Dimensions Publication ID

25 June 2017

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