Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK (Q24798788)

2

0 references

George Prendergast

3

0 references

Suzana Petanceska

4

0 references

Michelle E Ehrlich

5

0 references

Sam Gandy

Creative Commons Attribution 4.0 International

6

0 references

language of work or name

English

0 references

publication date

January 2005

0 references

published in

PLOS MEDICINE

0 references

volume

2

0 references

issue

1

0 references

page(s)

e18

0 references

copyright license

start time

11 January 2005

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 April 2017

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Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing

7 April 2017

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Alzheimer's disease: the cholesterol connection

7 April 2017

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

7 April 2017

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Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C

7 April 2017

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

7 April 2017

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7 April 2017

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APP processing and synaptic function

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7 April 2017

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Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

7 April 2017

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Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

7 April 2017

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Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding

28 September 2017

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Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

28 September 2017

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Current concepts and future prospects for Alzheimer disease vaccines

28 September 2017

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A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

28 September 2017

1 reference

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Cholesterol and the biology of Alzheimer's disease.

28 September 2017

1 reference

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Molecular and cellular basis for anti-amyloid therapy in Alzheimer disease

28 September 2017

1 reference

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

28 September 2017

1 reference

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RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate

28 September 2017

1 reference

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Implication of APP secretases in notch signaling

28 September 2017

1 reference

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Locking a leukocyte integrin with statins

28 September 2017

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

28 September 2017

1 reference

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

28 September 2017

1 reference

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Statins and the risk of dementia

28 September 2017

1 reference

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

28 September 2017

1 reference

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

28 September 2017

1 reference

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

28 September 2017

1 reference

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Activated release of membrane-anchored TGF-alpha in the absence of cytosol

28 September 2017

1 reference

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Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

28 September 2017

1 reference

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Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Cell-autonomous role of Notch, an epidermal growth factor homologue, in sensory organ differentiation in Drosophila

28 September 2017

1 reference

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

28 September 2017

1 reference

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Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.

30 May 2018

1 reference

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Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.

30 May 2018

1 reference

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30 May 2018

1 reference

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Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

30 May 2018

1 reference

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The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

30 May 2018

1 reference

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Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

30 May 2018

1 reference

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Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.

30 May 2018

1 reference

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Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

28 November 2018

1 reference

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Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Statin therapy for Alzheimer's disease: will it work?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Actin' up: RhoB in cancer and apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Serum lipoprotein levels, statin use, and cognitive function in older women

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

An inflammatory drug prospect

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=543463

Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15647781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15647781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15647781