Alpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts (Q24798834)

1

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Hironobu Ihn

2

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Kenichi Yamane

3

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Yoshihiro Mimura

4

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Yoshihide Asano

5

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Kunihiko Tamaki

Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts

6

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language of work or name

English

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publication date

2005

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published in

Nucleic Acids Research

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volume

33

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issue

4

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page(s)

1337-51

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cites work

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Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts

7 April 2017

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The transforming growth factor-beta family

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Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

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Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site

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Overlapping pathways mediate the opposing actions of tumor necrosis factor-alpha and transforming growth factor-beta on alpha 2(I) collagen gene transcription

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Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast

28 September 2017

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A protein kinase C isozyme is translocated to cytoskeletal elements on activation

28 September 2017

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Involvement of protein kinase C in the transcriptional regulation of 12-O-tetradecanoylphorbol-13-acetate-inducible genes modulated by AP-1 or non-AP-1 transacting factors

28 September 2017

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Smad3 and PKCdelta mediate TGF-beta1-induced collagen I expression in human mesangial cells

28 September 2017

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Regulation of retinoid X receptor responsive element-dependent transcription in T lymphocytes by Ser/Thr phosphatases: functional divergence of protein kinase C (PKC)theta; and PKC alpha in mediating calcineurin-induced transactivation

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Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.

30 May 2018

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Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter

30 May 2018

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Antagonistic regulation of a proline-rich transcription factor by transforming growth factor beta and tumor necrosis factor alpha

30 May 2018

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Functional analysis of cis-acting DNA sequences controlling transcription of the human type I collagen genes.

30 May 2018

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Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF beta 1 stimulation

30 May 2018

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High ambient glucose enhances sensitivity to TGF-beta1 via extracellular signal--regulated kinase and protein kinase Cdelta activities in human mesangial cells.

30 May 2018

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Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts

28 November 2018

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Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells

28 November 2018

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Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552962

IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552962

Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552962

Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta

28 November 2018

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Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=552962

Transcriptional activation of the alpha 1(I) procollagen gene in systemic sclerosis dermal fibroblasts. Role of intronic sequences

28 November 2018

1 reference

12 December 2020

Oncostatin M Stimulates Transcription of the Human α2(I) Collagen Gene via the Sp1/Sp3-binding Site

1 reference

12 December 2020

Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

1 reference

12 December 2020

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1 reference

12 December 2020

Anti-sclerotic effect of transforming growth factor-beta antibody in a mouse model of bleomycin-induced scleroderma

1 reference

12 December 2020

Fli-1 Inhibits Collagen Type I Production in Dermal Fibroblasts via an Sp1-dependent Pathway

1 reference

12 December 2020

Depletion of protein kinase Cepsilon in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression

1 reference

12 December 2020

Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway

1 reference

12 December 2020

Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine k

1 reference

12 December 2020

Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors

1 reference

12 December 2020

Antagonistic Effects of TNF-α on TGF-β Signaling Through Down-Regulation of TGF-β Receptor Type II in Human Dermal Fibroblasts

1 reference

12 December 2020

Immunologic aspects of scleroderma

1 reference

12 December 2020

Altered regulation of collagen metabolism in scleroderma fibroblasts grown within three-dimensional collagen gels

1 reference

12 December 2020

Characterization of a GC-rich Region Containing Sp1 Binding Site(s) as a Constitutive Responsive Element of the α2(I) Collagen Gene in Human Fibroblasts

1 reference

12 December 2020

Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts

1 reference

12 December 2020

Transcriptional Regulation of the Human α2(I) Collagen Gene

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKI275

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3249522

3249522

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1 reference

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