Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure (Q24804131)

2

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Roger J Hajjar

3

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Djamel Lebeche

4

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Klara Skiroman

5

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George Jabbour

6

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Angelia A Doye

7

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Michael X Lee

8

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Nancy Laste

9

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Judith K Gwathmey

Effect of beta-blockers on free radical-induced cardiac contractile dysfunction

10

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language of work or name

English

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publication date

21 July 2003

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published in

BMC Physiology

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volume

3

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issue

1

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page(s)

6

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cites work

1 reference

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Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell

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Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death

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Apoptosis in pressure overload-induced heart hypertrophy in the rat.

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Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.

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Transcriptional regulation during cardiac growth and development

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Oxidative stress as a mediator of apoptosis

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Beta-blockers in heart failure: promising or proved?

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Cell death in the failing heart: role of an unnatural growth response to overload.

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Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure

28 September 2017

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Death by design. Programmed cell death in cardiovascular biology and disease

30 May 2018

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Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators.

30 May 2018

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The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group

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Carvedilol improves left ventricular function and symptoms in chronic heart failure: a double-blind randomized study

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Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol. The Heart-Muscle Disease Study Group.

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Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice

28 November 2018

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Effects of carvedilol on systolic and diastolic left ventricular performance in idiopathic dilated cardiomyopathy or ischemic cardiomyopathy

28 November 2018

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12 December 2020

Life and death in the cardiovascular system

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12 December 2020

Apoptosis in the failing human heart

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12 December 2020

Angiotensin II induces apoptosis of adult ventricular myocytes in vitro

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12 December 2020

Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat

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12 December 2020

Apoptosis: basic mechanisms and implications for cardiovascular disease

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12 December 2020

Apoptosis in hypertensive heart disease

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12 December 2020

Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure

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12 December 2020

Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol

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12 December 2020

Furazolidone-induced cardiac dilatation in turkeys

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12 December 2020

Effects of furazolidone on the development of cardiomyopathies in turkey poults

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12 December 2020

Adrenergic effects on the biology of the adult mammalian cardiocyte

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12 December 2020

Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force

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12 December 2020

Pathophysiological and biochemical characterisation of an avian model of dilated cardiomyopathy: comparison to findings in human dilated cardiomyopathy

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12 December 2020

Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction

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12 December 2020

Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade

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12 December 2020

Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs

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12 December 2020

Apoptosis in myocytes in end-stage heart failure

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12 December 2020

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12 December 2020

Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol

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12 December 2020