Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancers (Q25255621)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16412252%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Hypoxia-inducible factor-1alpha polymorphisms and TSC1/2 mutations are complementary in head and neck cancers (English)

1 reference

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15 January 2020

0 references

6

1 reference

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15 January 2020

author name string

Carla Hebert

1

1 reference

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15 January 2020

Kathleen Norris

2

1 reference

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15 January 2020

Pallavi Parashar

3

1 reference

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15 January 2020

Robert A Ord

4

1 reference

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15 January 2020

Nikolaos G Nikitakis

5

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15 January 2020

language of work or name

English

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publication date

16 January 2006

1 reference

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15 January 2020

1 reference

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15 January 2020

volume

5

1 reference

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15 January 2020

issue

1

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page(s)

3

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OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

15 January 2020

cites work

1 reference

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A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation

7 April 2017

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The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity

7 April 2017

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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

7 April 2017

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

7 April 2017

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The use of dioxygen by HIF prolyl hydroxylase (PHD1)

7 April 2017

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

7 April 2017

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FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

7 April 2017

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7 April 2017

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Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

7 April 2017

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

7 April 2017

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

7 April 2017

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Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

7 April 2017

1 reference

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

7 April 2017

1 reference

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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin

7 April 2017

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Characterization and comparative analysis of the EGLN gene family

7 April 2017

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

7 April 2017

1 reference

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Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy

7 April 2017

1 reference

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The von Hippel-Lindau tumor suppressor gene

7 April 2017

1 reference

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Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

7 April 2017

1 reference

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

7 April 2017

1 reference

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Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis

7 April 2017

1 reference

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TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase

7 April 2017

1 reference

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

7 April 2017

1 reference

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Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck

7 April 2017

1 reference

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The Akt-mTOR tango and its relevance to cancer

28 September 2017

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Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/TSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations

28 September 2017

1 reference

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Rapamycin: an anti-cancer immunosuppressant?

28 September 2017

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Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes

28 September 2017

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Activation of hypoxia-induced transcription in normoxia

28 September 2017

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The genetic basis of kidney cancer: why is tuberous sclerosis complex often overlooked?

28 September 2017

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The tuberous sclerosis complex genes in tumor development

28 September 2017

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The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb

28 September 2017

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Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation

28 September 2017

1 reference

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Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369006

Dysregulation of hypoxia inducible factor-1alpha in head and neck squamous cell carcinoma cell lines correlates with invasive potential.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369006

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

28 September 2017

1 reference

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Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369006

Regulation of cell morphology and adhesion by the tuberous sclerosis complex (TSC1/2) gene products in human kidney epithelial cells through increased E-cadherin/beta-catenin activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369006

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369006

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369006

Reduction of expression of tuberin, the tuberous-sclerosis-complex-gene-2 product in tuberous sclerosis complex associated connective tissue nevi and sporadic squamous and basal cell carcinomas.

28 September 2017

1 reference

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Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma.

31 May 2018

1 reference

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Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype

28 November 2018

1 reference

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

28 November 2018

1 reference

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Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16412252

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16412252

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-5-3

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

870355

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16412252%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 January 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/1476-4598-5-3

OpenCitations bibliographic resource ID

9 September 2019

870355

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16412252%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

16412252

1 reference