Activation of hypoxia-induced transcription in normoxia (Q40426107)

20 September 2017

Activation of hypoxia-induced transcription in normoxia (English)

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20 September 2017

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Maria Hägg

1

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PubMed ID

15878343

20 September 2017

Stefan Wennström

series ordinal

2

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PubMed ID

15878343

20 September 2017

language of work or name

English

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publication date

19 March 2005

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Experimental Cell Research

20 September 2017

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20 September 2017

306

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20 September 2017

180-191

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20 September 2017

1

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Hypoxia--a key regulatory factor in tumour growth

20 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Suppression of tumor growth through disruption of hypoxia-inducible transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

A conserved family of prolyl-4-hydroxylases that modify HIF

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

The von Hippel-Lindau tumor suppressor protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Molecular basis of the VHL hereditary cancer syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: implications for HIF-1alpha gene therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.01.017

10.1016/J.YEXCR.2005.01.017

7 January 2021

Identifiers

DOI

1 reference

20 September 2017

1 reference

PubMed ID

15878343