Huntingtin (Q2620886)

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mammalian protein found in Homo sapiens
  • huntingtin
  • HTT
  • HD protein
  • huntington disease protein
  • Htt1
edit
Language Label Description Also known as
English
Huntingtin
mammalian protein found in Homo sapiens
  • huntingtin
  • HTT
  • HD protein
  • huntington disease protein
  • Htt1

Statements

molecular function
protein binding
determination method
IPI
30 references
retrieved
8 April 2019
stated in
Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
The cryo-electron microscopy structure of huntingtin
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Polyglutamine expansion of huntingtin impairs its nuclear export
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
A huntingtin-associated protein enriched in brain with implications for pathology
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin promotes cell survival by preventing Pak2 cleavage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Polyglutamine tracts regulate beclin 1-dependent autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
α-Synuclein modifies huntingtin aggregation in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
A human HAP1 homologue. Cloning, expression, and interaction with huntingtin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Association of HAP1 isoforms with a unique cytoplasmic structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into the specific binding of huntingtin proline-rich region with the SH3 and WW domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Development and application of a DNA microarray-based yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
retrieved
8 April 2019
stated in
HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IEA
retrieved
8 April 2019
stated in
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IDA
retrieved
8 April 2019
stated in
Huntingtin contains a highly conserved nuclear export signal
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IDA
retrieved
8 April 2019
stated in
Polyglutamine expansion of huntingtin impairs its nuclear export
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IDA
cytoplasm
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IEA
retrieved
8 April 2019
stated in
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IDA
retrieved
8 April 2019
stated in
SUMO modification of Huntingtin and Huntington's disease pathology
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IDA
retrieved
8 April 2019
stated in
Polyglutamine expansion of huntingtin impairs its nuclear export
GOA
curator
UniProt
UniProt protein ID
P42858
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42858
determination method
IDA
biological process
Gene Atlas image
PBB GE HD 202389 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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