Definition of a molecular pathway mediating α-synuclein neurotoxicity (Q26269832)

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4380997/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4380997/fullTextXML

inferred from PubMed Central ID database lookup

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Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model t

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 November 2018

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28 September 2017

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28 September 2017

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Structure and dynamics of micelle-bound human alpha-synuclein

28 September 2017

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Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

28 September 2017

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Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

28 September 2017

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Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

28 September 2017

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28 September 2017

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

28 September 2017

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alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

28 September 2017

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Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

28 September 2017

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A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor

28 September 2017

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Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

28 September 2017

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

28 September 2017

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

28 September 2017

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

28 September 2017

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

28 September 2017

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Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

28 September 2017

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A simple method for the preparation of homogeneous phospholipid vesicles

28 September 2017

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Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

28 September 2017

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Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein

31 May 2018

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NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

31 May 2018

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Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

31 May 2018

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Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties

28 November 2018

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The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

28 November 2018

1 reference

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Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis

28 November 2018

1 reference

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Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Lipid binding inhibits alpha-synuclein fibril formation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Membrane binding and self-association of alpha-synucleins.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Multiple-system atrophy: a new alpha-synuclein disease?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Evidence that the precursor protein of non-A beta component of Alzheimer's disease amyloid (NACP) has an extended structure primarily composed of random-coil.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4380997

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25834048

12 December 2020

inferred from PubMed ID database lookup

alpha-Synuclein membrane interactions and lipid specificity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25834048

12 December 2020

inferred from PubMed ID database lookup

Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25834048

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.4650-14.2015

1 reference

1 reference

1 reference

PubMed publication ID

25834048

1 reference