Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD) (Q26752685)

25 April 2019

28 September 2019

8 October 2022

on focus list of Wikimedia project

7 February 2024

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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

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Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila

7 April 2017

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The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy

7 April 2017

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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

7 April 2017

1 reference

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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

7 April 2017

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Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

7 April 2017

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Missing pieces in the Parkinson's disease puzzle

7 April 2017

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

7 April 2017

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Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor

7 April 2017

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A review of Parkinson's disease

7 April 2017

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Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

7 April 2017

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Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death

7 April 2017

1 reference

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Dopamine covalently modifies and functionally inactivates parkin

7 April 2017

1 reference

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

7 April 2017

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How does parkin ligate ubiquitin to Parkinson's disease?

7 April 2017

1 reference

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Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region

7 April 2017

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

7 April 2017

1 reference

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

7 April 2017

1 reference

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The F-box protein family.

7 April 2017

1 reference

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

7 April 2017

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

7 April 2017

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Protein degradation pathways in Parkinson's disease: curse or blessing

7 April 2017

1 reference

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Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Structure of parkin reveals mechanisms for ubiquitin ligase activation

7 April 2017

1 reference

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The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15)

7 April 2017

1 reference

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FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy

7 April 2017

1 reference

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F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy

7 April 2017

1 reference

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FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination

7 April 2017

1 reference

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Septins: the fourth component of the cytoskeleton

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The septin family of GTPases: architecture and dynamics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

F-box proteins: the key to protein degradation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Lewy bodies and parkinsonism in families with parkin mutations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Parkinson's disease: mechanisms and models

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Association between early-onset Parkinson's disease and mutations in the parkin gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The future of cell therapies and brain repair: Parkinson's disease leads the way.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Mechanisms and function of substrate recruitment by F-box proteins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

F-box only protein 7 gene in parkinsonian-pyramidal disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Autosomal recessive parkinsonism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

What genetics tells us about the causes and mechanisms of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Novel ATP13A2 (PARK9) homozygous mutation in a family with marked phenotype variability

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Roles of the ubiquitin-proteosome system in neurogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Protein homeostasis and aging in neurodegeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Genetic animal models of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Protein degradation in Parkinson disease revisited: it's complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

L-dopa therapy for Parkinson's disease: past, present, and future

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The insulin paradox: aging, proteotoxicity and neurodegeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

PARK2 mutations and clinical features in a Chinese population with early-onset Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Role of the ubiquitin proteasome system in Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Pathogenic mutations in Parkinson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Are ubiquitination pathways central to Parkinson's disease?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Complex relationship between Parkin mutations and Parkinson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Pathogenesis of dyskinesias in Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Neuroprotection of Parkin against apoptosis is independent of inclusion body formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

The many faces of alpha-synuclein mutations

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

A severe and irreversible case of tardive rigid-akinetic parkinsonian syndrome: the role of the DaTscan

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

Characterization of the porcine FBX07 gene: the first step towards generation of a pig model for Parkinsonian pyramidal syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

A new F-box protein 7 gene mutation causing typical Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

Differentiating symptomatic Parkin mutations carriers from patients with idiopathic Parkinson's disease: contribution of automated segmentation neuroimaging method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

Parkin disease: a phenotypic study of a large case series

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

Case-control study of the parkin gene in early-onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

The parkin gene and its phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS13041-016-0218-2

Mutational analysis of FBXO7 gene in Parkinson's disease in a Taiwanese population.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Parkin mutations and phenotypic features in Czech patients with early-onset Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4835861

Methods for studying prion protein (PrP) metabolism and the formation of protease-resistant PrP in cell culture and cell-free systems. An update

28 November 2018

1 reference

12 December 2020

Animal models of Parkinson's disease

1 reference

12 December 2020

PARK2 gene mutations in early onset Parkinson's disease patients of South India

1 reference

12 December 2020

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration

1 reference

12 December 2020

10.1186/S13041-016-0218-2

Identifiers

DOI

1 reference

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s13041-016-0218-2

1 reference

1 reference

PubMed publication ID

27090516

1 reference