Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation (Q26781130)

25 April 2019

25 June 2019

19 December 2019

20 December 2019

9 September 2020

on focus list of Wikimedia project

8 October 2022

ScienceSource

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cites work

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Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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Stages in the development of Parkinson's disease-related pathology

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Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

7 April 2017

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Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease

28 September 2017

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Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.

28 September 2017

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Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models

28 September 2017

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ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

28 September 2017

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28 September 2017

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28 September 2017

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Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

28 September 2017

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Neuronal activity regulates extracellular tau in vivo

28 September 2017

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Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials

28 September 2017

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28 September 2017

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28 September 2017

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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease

28 September 2017

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α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model

28 September 2017

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α-Synuclein: the long distance runner

28 September 2017

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Developing therapeutic antibodies for neurodegenerative disease

28 September 2017

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Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

28 September 2017

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

28 September 2017

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A novel α-synuclein missense mutation in Parkinson disease

28 September 2017

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Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies

28 September 2017

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Neural and immune mechanisms in the pathogenesis of Parkinson's disease.

28 September 2017

1 reference

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

28 September 2017

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Alpha-synuclein: from secretion to dysfunction and death

28 September 2017

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Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy

28 September 2017

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Engaging neuroscience to advance translational research in brain barrier biology.

28 September 2017

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Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier

28 September 2017

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Microglia in neurodegenerative disease

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4923719

Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

28 September 2017

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Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4923719

The transcellular spread of cytosolic amyloids, prions, and prionoids

28 September 2017

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Prion-like mechanisms in neurodegenerative diseases

28 September 2017

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Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

28 September 2017

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Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.

28 September 2017

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Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4923719

Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment

28 September 2017

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Synuclein activates microglia in a model of Parkinson's disease

28 September 2017

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Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation

28 September 2017

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Microglial phenotype: is the commitment reversible?

28 September 2017

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Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

28 September 2017

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Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

28 September 2017

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Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

28 September 2017

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Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier

28 September 2017

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Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations

28 September 2017

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

28 September 2017

1 reference

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The cell biology of the blood-brain barrier.

28 September 2017

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Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels

28 September 2017

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Fine structural localization of a blood-brain barrier to exogenous peroxidase

28 September 2017

1 reference

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

28 September 2017

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Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

31 May 2018

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Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

31 May 2018

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Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

31 May 2018

1 reference

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Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

21 January 2018

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-150630

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.3233%2FJPD-150630

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Neurotrophic and neuroprotective actions of estrogens and their therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Transferrin receptor on endothelium of brain capillaries

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJPD-150630

α-synuclein imaging: a critical need for Parkinson's disease research

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4923719

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4923719

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

28 November 2018

1 reference

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https://pubmed.ncbi.nlm.nih.gov/26406122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanisms, Clinical Strategies, and Promising Treatments of Neurodegenerative Diseases. 12th International Conference AD/PD Nice, France, March 18-22, 2015: Abstracts

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PubMed

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