Microglia in neurodegenerative disease (Q37710380)

22 August 2017

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title

Microglia in neurodegenerative disease (English)

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22 August 2017

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V Hugh Perry

1

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22 August 2017

James A R Nicoll

series ordinal

2

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22 August 2017

Clive Holmes

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

16 March 2010

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22 August 2017

Nature Reviews Neurology

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22 August 2017

6

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22 August 2017

193-201

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22 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2010.17

22 August 2017

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Monocyte and macrophage heterogeneity

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Exploring the full spectrum of macrophage activation

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Microglial physiology: unique stimuli, specialized responses

31 March 2020

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

31 March 2020

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Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

31 March 2020

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Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

31 March 2020

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

31 March 2020

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ATP mediates rapid microglial response to local brain injury in vivo

31 March 2020

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Turnover of resident microglia in the normal adult mouse brain

31 March 2020

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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.

31 March 2020

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Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

31 March 2020

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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

31 March 2020

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Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.

31 March 2020

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CD200 and membrane protein interactions in the control of myeloid cells

31 March 2020

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Down-regulation of the macrophage lineage through interaction with OX2 (CD200)

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.

31 March 2020

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Microglial senescence: does the brain's immune system have an expiration date?

31 March 2020

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Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

31 March 2020

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Microglia: a sensor for pathological events in the CNS

31 March 2020

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PK ('peripheral benzodiazepine')--binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK11195 binding to activated microglia

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Visualising microglial activation in vivo

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

31 March 2020

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Macrophage activation and polarization

31 March 2020

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Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences

31 March 2020

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Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages

31 March 2020

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The immunopathology of multiple sclerosis: an overview

31 March 2020

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Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.

31 March 2020

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DAMPs, PAMPs and alarmins: all we need to know about danger

31 March 2020

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How dying cells alert the immune system to danger

31 March 2020

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Recognition of microorganisms and activation of the immune response

31 March 2020

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Intracellular pattern recognition receptors in the host response

31 March 2020

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Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Inflammation in central nervous system injury

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

The inflammatory response in stroke

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion.

31 March 2020

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The long-distance effects of brain lesions: visualization of myelinated pathways in the human brain using polarizing and fluorescence microscopy.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Protective effects of NSAIDs on the development of Alzheimer disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development?

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Serum amyloid P immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

NSAID use and the risk of Parkinson's disease: systematic review and meta-analysis of observational studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Onset and progression in inherited ALS determined by motor neurons and microglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Inflammation and Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Apoptosis and caspases in neurodegenerative diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

A blast from the past: clearance of apoptotic cells regulates immune responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Mice as models: transgenic approaches and Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

The value of incomplete mouse models of Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Systemic infections and inflammation affect chronic neurodegeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

The facial nerve axotomy model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Degenerating synaptic boutons in prion disease: microglia activation without synaptic stripping

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Colony-stimulating factors in inflammation and autoimmunity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Microgliosis: the questions shape the answers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Cerebral and peripheral amyloid phagocytes--an old liaison with a new twist.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Vaccines for Alzheimer's disease: how close are we?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

From inflammation to sickness and depression: when the immune system subjugates the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Delirium in elderly adults: diagnosis, prevention and treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Delirium superimposed on dementia: a systematic review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Delirium accelerates cognitive decline in Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Systemic inflammation and disease progression in Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease: an epidemiological perspective

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

The epidemiology of the dementias: an update

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Cognitive dysfunction and diabetes mellitus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Vascular risk factors and Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.17

Alzheimer's disease and peripheral infections: the possible contribution from periodontal infections, model and hypothesis

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20234358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Transforming growth factor-beta is involved in the pathogenesis of dialysis-related amyloidosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20234358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20234358

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRNEUROL.2010.17

1 reference

22 August 2017

1 reference