Anti-PEG immunity: emergence, characteristics, and unaddressed questions (Q26825556)

21 June 2017

1 reference

title

Anti-PEG immunity: emergence, characteristics, and unaddressed questions (English)

1 reference

21 June 2017

Qi Yang

1

1 reference

21 June 2017

Samuel K Lai

series ordinal

2

1 reference

21 June 2017

language of work or name

1 reference

23 February 2015

1 reference

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

21 June 2017

published in

1 reference

21 June 2017

volume

7

1 reference

21 June 2017

issue

5

1 reference

21 June 2017

page(s)

655-677

1 reference

PEGylation, successful approach to drug delivery

21 June 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Impact of large aggregated uricases and PEG diol on accelerated blood clearance of PEGylated canine uricase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

General in vitro method to analyze the interactions of synthetic polymers with human antibody repertoires

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

The immunogenicity of polyethylene glycol: facts and fiction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Accelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Recent advances in stealth coating of nanoparticle drug delivery systems

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Nanoparticle PEGylation for imaging and therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Pathogen-mimetic stealth nanocarriers for drug delivery: a future possibility

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Parameters influencing the stealthiness of colloidal drug delivery systems

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Effect of pegylation on pharmaceuticals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Induction of CD4(+) T-cell-independent immunoglobulin responses by inactivated influenza virus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Hydration of polyethylene glycol-grafted liposomes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

PEG-ing down (and preventing?) the cause of pegloticase failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Role of the methoxy group in immune responses to mPEG-protein conjugates

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

T-cell-independent immune responses do not require CXC ligand 13-mediated B1 cell migration

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol).

31 May 2018

1 reference

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

21 January 2018

1 reference

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents.

21 January 2018

1 reference

Conformational studies of covalently grafted poly(ethylene glycol) on modified solid matrices using X-ray photoelectron spectroscopy.

21 January 2018

1 reference

Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation.

21 January 2018

1 reference

A single dose of intravenously injected poloxamine-coated long-circulating particles triggers macrophage clearance of subsequent doses in rats.

21 January 2018

1 reference

Accelerated clearance of a second injection of PEGylated liposomes in mice

21 January 2018

1 reference

Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic Acid

21 January 2018

1 reference

Hemoglobin vesicles, polyethylene glycol (PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice

21 January 2018

1 reference

A noticeable phenomenon: thiol terminal PEG enhances the immunogenicity of PEGylated emulsions injected intravenously or subcutaneously into rats

21 January 2018

1 reference

Accelerated blood clearance of PEGylated PLGA nanoparticles following repeated injections: effects of polymer dose, PEG coating, and encapsulated anticancer drug.

21 January 2018

1 reference

Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes.

21 January 2018

1 reference

Comprehensive analysis of PEGylated liposome-associated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods.

21 January 2018

1 reference

Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

21 January 2018

1 reference

Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins.

21 January 2018

1 reference

Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients

21 January 2018

1 reference

Effect of siRNA in PEG-coated siRNA-lipoplex on anti-PEG IgM production

21 January 2018

1 reference

CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes

21 January 2018

1 reference

Repeated injection of pegylated liposomal antitumour drugs induces the disappearance of the rapid distribution phase

21 January 2018

1 reference

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles

21 January 2018

1 reference

Evasion of the Accelerated Blood Clearance Phenomenon by Coating of Nanoparticles with Various Hydrophilic Polymers

21 January 2018

1 reference

Idiotype‐specific CD4+CD25+ T suppressor cells prevent, by limiting antibody diversity, the occurrence of anti‐dextran antibodies crossreacting with histone H3

21 January 2018

1 reference

Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon

21 January 2018

1 reference

Influence of phospholipid types and animal models on the accelerated blood clearance phenomenon of PEGylated liposomes upon repeated injection

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Repeated injections of PEG-PE liposomes generate anti-PEG antibodies.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515207

Repulsive interactions and mechanical stability of polymer-grafted lipid membranes

28 November 2018

1 reference

12 December 2020

Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes

1 reference

12 December 2020

PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner

1 reference

12 December 2020

Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

1 reference

12 December 2020

Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles

1 reference

12 December 2020

Re-establishing the long circulatory behaviour of poloxamine-coated particles after repeated intravenous administration: applications in cancer drug delivery and imaging

1 reference

12 December 2020

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

1 reference

12 December 2020

Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon

1 reference

12 December 2020

XPS and AFM analysis of antifouling PEG interfaces for microfabricated silicon biosensors

1 reference

12 December 2020

Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors

1 reference

12 December 2020

Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application

1 reference

12 December 2020

A frustrating problem: accelerated blood clearance of PEGylated solid lipid nanoparticles following subcutaneous injection in rats

1 reference

12 December 2020

Efficient clearance of poly(ethylene glycol)-modified immunoenzyme with anti-PEG monoclonal antibody for prodrug cancer therapy

1 reference

12 December 2020

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout

1 reference

12 December 2020

Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance

1 reference

12 December 2020

Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection

1 reference

12 December 2020

Generation and characterization of a monoclonal IgG antibody to polyethylene glycol

1 reference

12 December 2020

Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes

1 reference

12 December 2020

Antibodies against polyethylene glycol produced in animals by immunization with monomethoxy polyethylene glycol modified proteins

1 reference

12 December 2020

Accelerated blood clearance of pegylated liposomal topotecan: influence of polyethylene glycol grafting density and animal species

1 reference

12 December 2020

The influence of repeated injections on pharmacokinetics and biodistribution of different types of sterically stabilized immunoliposomes

1 reference

12 December 2020

Accelerated clearance of PEGylated liposomes in rats after repeated injections

1 reference

12 December 2020

Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM

1 reference

12 December 2020

Intravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M response

1 reference

12 December 2020

The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats

1 reference

12 December 2020

Identifiers

DOI

10.1002/WNAN.1339

1 reference

OpenCitations bibliographic resource ID

21 June 2017

2638520

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2638520

1 reference