Insulin: an emerging treatment for Alzheimer's disease dementia? (Q26827376)

Jeffrey M. Burns

series ordinal

2

1 reference

language of work or name

1 reference

October 2012

1 reference

Current Neurology and Neuroscience Reports

published in

1 reference

volume

12

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issue

5

1 reference

page(s)

520-7

1 reference

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin signalling and the regulation of glucose and lipid metabolism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

β-Amyloid burden in healthy aging: regional distribution and cognitive consequences.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin resistance in the nervous system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

GSK3 and Alzheimer's Disease: Facts and Fiction….

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Type 2 diabetes and late-onset Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin is differentially related to cognitive decline and atrophy in Alzheimer's disease and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Mid- and late-life diabetes in relation to the risk of dementia: a population-based twin study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Pioglitazone and sulfonylureas: effectively treating type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Measures of insulin sensitivity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin signaling in the central nervous system: learning to survive

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Intranasal insulin improves memory in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

28 September 2017

https://pubmed.ncbi.nlm.nih.gov/22791280

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sniffing neuropeptides: a transnasal approach to the human brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Type 2 diabetes mellitus, cognitive impairment and dementia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Recruitment of functional GABA(A) receptors to postsynaptic domains by insulin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Risk of dementia among persons with diabetes mellitus: a population-based cohort study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin receptors in the mammalian central nervous system: binding characteristics and subunit structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin receptors in the brain: structural and physiological characterization

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Rapid bidirectional effects of insulin on hypothalamic noradrenergic and serotoninergic neuronal activity in the rat: role in glucose homeostasis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3.

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Relation of diabetes to mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Diabetes, impaired fasting glucose, and development of cognitive impairment in older women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Impaired insulin secretion increases the risk of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Insulin increases CSF Abeta42 levels in normal older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Improving influence of insulin on cognitive functions in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Memory improvement following induced hyperinsulinemia in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Intranasal insulin improves memory in humans: superiority of insulin aspart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

A multi-center randomized proof-of-concept clinical trial applying [¹⁸F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Apolipoprotein E polymorphism modulates the association between obesity and dyslipidemias during young adulthood: The Bogalusa Heart Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Inhibition of insulin signaling by oxidized low density lipoprotein. Protective effect of the antioxidant Vitamin E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Improving metabolic control leads to better working memory in adults with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11910-012-0297-0

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3540744

Amyloid beta oligomers induce impairment of neuronal insulin receptors

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22791280

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22791280

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11910-012-0297-0

0 references

Dimensions Publication ID

0 references

1 reference

PubMed publication ID

22791280

1 reference