Insulin signalling and the regulation of glucose and lipid metabolism (Q24292020)

Solute carrier family 2 member 4

GOA release 2020-03-11

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negative regulation of insulin receptor signaling pathway

GOA release 2020-03-11

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GOA release 2020-03-11

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2

C R Kahn

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author name string

A R Saltiel

series ordinal

1

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language of work or name

English

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publication date

13 December 2001

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number of pages

8

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Glucose transport and glucose transporters in muscle and their metabolic regulation

inferred from page(s)

published in

Nature

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volume

414

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page(s)

799-806

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issue

6865

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cites work

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7 January 2021

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

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7 January 2021

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

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7 January 2021

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

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7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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7 January 2021

The insulin receptor--a critical link in glucose homeostasis and insulin action

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7 January 2021

Minireview: tissue-specific versus generalized gene targeting of the igf1 and igf1r genes and their roles in insulin-like growth factor physiology

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7 January 2021

Origin of insulin receptor-like tyrosine kinases in marine sponges.

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7 January 2021

The IRS-signalling system: a network of docking proteins that mediate insulin action

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7 January 2021

Signaling pathways in insulin action: molecular targets of insulin resistance

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7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

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7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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7 January 2021

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

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7 January 2021

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

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7 January 2021

Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes

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7 January 2021

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

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7 January 2021

Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

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7 January 2021

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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7 January 2021

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

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7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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7 January 2021

Prevention of fat-induced insulin resistance by salicylate

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7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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7 January 2021

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

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7 January 2021

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

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7 January 2021

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

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7 January 2021

Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

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7 January 2021

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

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7 January 2021

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

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7 January 2021

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

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7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

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7 January 2021

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

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7 January 2021

Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase

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7 January 2021

Kinase phosphorylation: Keeping it all in the family

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7 January 2021

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

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7 January 2021

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

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7 January 2021

The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells

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7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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7 January 2021

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

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7 January 2021

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

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7 January 2021

Role of the Src homology 2 (SH2) domain and C-terminus tyrosine phosphorylation sites of SH2-containing inositol phosphatase (SHIP) in the regulation of insulin-induced mitogenesis

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7 January 2021

The lipid phosphatase SHIP2 controls insulin sensitivity

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7 January 2021

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

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7 January 2021

A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions

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7 January 2021

Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene

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7 January 2021

The sorbin homology domain: a motif for the targeting of proteins to lipid rafts

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7 January 2021

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

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7 January 2021

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

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7 January 2021

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation

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7 January 2021

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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7 January 2021

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

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7 January 2021

The target of rapamycin (TOR) proteins

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7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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7 January 2021

TOR signalling and control of cell growth

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7 January 2021

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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7 January 2021

The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action.

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7 January 2021

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1

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7 January 2021

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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7 January 2021

Free fatty acids and pathogenesis of type 2 diabetes mellitus

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7 January 2021

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

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7 January 2021

New connections in the regulation of PEPCK gene expression by insulin

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7 January 2021

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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7 January 2021

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

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7 January 2021

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

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7 January 2021

Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro

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7 January 2021

Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt

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7 January 2021

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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7 January 2021

Syndromes associated with insulin resistance and acanthosis nigricans

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7 January 2021

Strategies and prospects for finding insulin resistance genes

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7 January 2021

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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7 January 2021

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease

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7 January 2021

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

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7 January 2021

Role of brain insulin receptor in control of body weight and reproduction.

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7 January 2021

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

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7 January 2021

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

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7 January 2021

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

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7 January 2021

Cellular mechanisms of insulin resistance

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7 January 2021

Regional differences in intramyocellular lipids in humans observed by in vivo 1H-MR spectroscopic imaging

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7 January 2021

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

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7 January 2021

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

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7 January 2021

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

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7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

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7 January 2021

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

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7 January 2021

Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia

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7 January 2021

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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7 January 2021

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

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7 January 2021

Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.

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7 January 2021

A family of tissue-specific resistin-like molecules

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7 January 2021

Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle

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7 January 2021

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development

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7 January 2021

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

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7 January 2021

Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location!

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7 January 2021

Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes

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7 January 2021

Identifiers

DOI

10.1038/414799A

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

544975

1000331422

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Fatcat ID

release_tveio2ybpfcqbkmvjcnmvc7ckm

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Fatcat

https://api.fatcat.wiki/v0/release/tveio2ybpfcqbkmvjcnmvc7ckm

24 November 2022

mapped directly with Wikidata item

544975

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference