The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma (Q26827928)

Sorin Armeanu-Ebinger

series ordinal

2

1 reference

Jörg Fuchs

series ordinal

3

1 reference

International Journal of Molecular Sciences

language of work or name

1 reference

16 February 2015

8 references

3 April 2019

9 September 2019

17 September 2019

7 November 2019

12 November 2019

26 October 2020

17 December 2020

8 references

3 April 2019

9 September 2019

17 September 2019

7 November 2019

12 November 2019

26 October 2020

17 December 2020

16

1 reference

issue

2

1 reference

page(s)

4190-208

1 reference

Creative Commons Attribution

copyright license

7 references

3 April 2019

9 September 2019

17 September 2019

7 November 2019

12 November 2019

26 October 2020

17 December 2020

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers

7 April 2017

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Progress in the treatment of elderly/unfit chronic lymphocytic leukemia patients: results of the German CLL-11 trial

28 September 2017

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ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in "double hit" lymphoma cells

28 September 2017

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ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

28 September 2017

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A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia

28 September 2017

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Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia

28 September 2017

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A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia

28 September 2017

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Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer

28 September 2017

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Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression.

28 September 2017

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Randomized phase II study of carboplatin and etoposide with or without obatoclax mesylate in extensive-stage small cell lung cancer

28 September 2017

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Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells

28 September 2017

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Hepatoblastoma state of the art: pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation.

28 September 2017

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Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro

28 September 2017

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A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer

28 September 2017

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Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study

28 September 2017

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Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenografts

28 September 2017

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Increased efficacy of CDDP in a xenograft model of hepatoblastoma using the apoptosis sensitizer ABT-737.

28 September 2017

1 reference

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The activity of γδ T cells against paediatric liver tumour cells and spheroids in cell culture

28 September 2017

1 reference

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Current and future management strategies for relapsed or progressive hepatoblastoma

28 September 2017

1 reference

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Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation

28 September 2017

1 reference

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Proteasome inhibition overcomes TRAIL resistance in human hepatoblastoma cells.

28 September 2017

1 reference

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Apoptosis in cancer: from pathogenesis to treatment

28 September 2017

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The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma

28 September 2017

1 reference

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Inhibition of Bcl-2 and Bcl-X enhances chemotherapy sensitivity in hepatoblastoma cells

28 September 2017

1 reference

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Opposing effects of bim and bcl-2 on lung endothelial cell migration

28 September 2017

1 reference

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Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death

28 September 2017

1 reference

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Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma

28 September 2017

1 reference

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Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation

28 September 2017

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Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer

28 September 2017

1 reference

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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

28 September 2017

1 reference

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Mimicking the BH3 domain to kill cancer cells

28 September 2017

1 reference

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Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival

28 September 2017

1 reference

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Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.

28 September 2017

1 reference

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Programmed cell death pathways and current antitumor targets

28 September 2017

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Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells

28 September 2017

1 reference

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Adenovirus-mediated cytosine deaminase/5-fluorocytosine suicide gene therapy of human hepatoblastoma in vitro.

28 September 2017

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Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways

28 September 2017

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Molecular targets for epigenetic therapy of cancer

28 September 2017

1 reference

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Oncolytic virotherapy for advanced liver tumours.

28 September 2017

1 reference

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Mechanisms of proteasome inhibitor action and resistance in cancer

28 September 2017

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28 September 2017

Liver tumors in children

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Chemotherapy in the treatment of locally advanced head and neck cancer

28 September 2017

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Redefining the role of doxorubicin for the treatment of children with hepatoblastoma

28 September 2017

1 reference

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Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

28 September 2017

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Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

28 September 2017

1 reference

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Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

28 September 2017

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sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

28 September 2017

1 reference

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Bcl-2 gene silencing in pediatric epithelial liver tumors.

28 September 2017

1 reference

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Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1.

28 September 2017

1 reference

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The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

28 September 2017

1 reference

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HA14-1, a small molecule inhibitor of Bcl-2, bypasses chemoresistance in leukaemia cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

Bcl-2 expression modulates cell adhesion and migration promoting branching of ureteric bud cells

28 September 2017

1 reference

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Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

28 September 2017

1 reference

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Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma

28 September 2017

1 reference

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HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL.

28 September 2017

1 reference

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Bcl-2 is a key regulator for the retinoic acid-induced apoptotic cell death in neuroblastoma

28 September 2017

1 reference

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Efficiency of recombinant human TNF in human cancer therapy

28 September 2017

1 reference

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Management of liver tumors in childhood

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

In vitro gene targeting in human hepatoblastoma.

28 September 2017

1 reference

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Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the International Society of Pediatric Oncology Liver Tumor Study Group SIOPEL-1 study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

The role of glutathione-S-transferase in anti-cancer drug resistance

28 September 2017

1 reference

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Differentiated treatment protocols for high- and standard-risk hepatoblastoma--an interim report of the German Liver Tumor Study HB99

28 September 2017

1 reference

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

A new method of antitumor therapy with a high dose of TNF perfusion for unresectable liver tumors

28 September 2017

1 reference

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Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

28 September 2017

1 reference

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Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair

28 September 2017

1 reference

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Cellular determinants of sensitivity and resistance to DNA topoisomerase inhibitors

28 September 2017

1 reference

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Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma

28 September 2017

1 reference

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Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

ABT-199: taking dead aim at BCL-2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

Guidelines for surgical treatment of hepatoblastoma in the modern era--recommendations from the Childhood Liver Tumour Strategy Group of the International Society of Paediatric Oncology (SIOPEL).

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

Liver cancer in European children: incidence and survival, 1978-1997. Report from the Automated Childhood Cancer Information System project.

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Risk-adapted treatment for childhood hepatoblastoma. final report of the second study of the International Society of Paediatric Oncology--SIOPEL 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Pretreatment prognostic factors for children with hepatoblastoma-- results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Pretreatment prognostic factors and treatment results in children with hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Increased expression of multidrug resistance-associated genes after chemotherapy in pediatric solid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Identification of chelerythrine as an inhibitor of BclXL function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Different forms of cell death induced by putative BCL2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Apoptosis sensitizers enhance cytotoxicity in hepatoblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

Prognostic impact of molecular genetic alterations in hepatoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16024190

The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4346952

Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach--results of the first prospective study of the International Society of Pediatric Oncology

28 November 2018

1 reference

12 December 2020

Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma

1 reference

12 December 2020

Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group

1 reference

12 December 2020

Prognostic factors and staging systems in childhood hepatoblastoma

1 reference

12 December 2020

Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study

1 reference

12 December 2020

Allogeneic graft-versus-hepatoblastoma effect

1 reference

12 December 2020

Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

1 reference

12 December 2020

Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma

1 reference

12 December 2020

Effective cisplatin (DDP) based chemotherapy in the treatment of hepatoblastoma

1 reference

12 December 2020

BH3 mimetics reduce adhesion and migration of hepatoblastoma and hepatocellular carcinoma cells

1 reference

12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS16024190

1 reference

1 reference

1 reference

PubMed publication ID

25690034

1 reference