sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell (Q40150613)

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scientific article published on 26 November 2007

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English	sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell	scientific article published on 26 November 2007

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scholarly article

1 reference

Europe PubMed Central

18 September 2017

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell (English)

1 reference

Europe PubMed Central

18 September 2017

apoptotic process

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1 reference

based on heuristic

inferred from title

author name string

Defeng Tian

1

1 reference

Europe PubMed Central

18 September 2017

Sonia G Das

2

1 reference

Europe PubMed Central

18 September 2017

Jignesh M Doshi

3

1 reference

Europe PubMed Central

18 September 2017

Jun Peng

4

1 reference

Europe PubMed Central

18 September 2017

Jialing Lin

5

1 reference

Europe PubMed Central

18 September 2017

Chengguo Xing

6

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Europe PubMed Central

18 September 2017

language of work or name

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publication date

26 November 2007

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Europe PubMed Central

18 September 2017

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Europe PubMed Central

18 September 2017

259

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Europe PubMed Central

18 September 2017

2

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Europe PubMed Central

18 September 2017

198-208

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Europe PubMed Central

18 September 2017

Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.

1 reference

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Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: a promising new approach to the treatment of multidrug resistant cancer

1 reference

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Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer

1 reference

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Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor

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Apoptosis: biochemical aspects and clinical implications

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Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

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Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

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The Bcl-2 protein family: arbiters of cell survival

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Two CD95 (APO-1/Fas) signaling pathways

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.

1 reference

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The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

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Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18037229

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Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay

1 reference

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Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18037229

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Identifiers

10.1016/J.CANLET.2007.10.012

1 reference

Europe PubMed Central

18 September 2017

1 reference

Europe PubMed Central

18 September 2017

1 reference

Europe PubMed Central

18 September 2017

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