An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints (Q26828043)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23483579%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints (English)

2 references

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25 February 2020

3

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25 February 2020

author name string

Nam Vo

1

2 references

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25 February 2020

Lloydine Jacobs

4

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25 February 2020

James Kang

6

2 references

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25 February 2020

Laura J Niedernhofer

2

1 reference

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25 February 2020

Paul D Robbins

5

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25 February 2020

Christopher H Evans

7

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25 February 2020

language of work or name

1 reference

11 March 2013

1 reference

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Journal of Orthopaedic Research

25 February 2020

published in

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25 February 2020

volume

31

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25 February 2020

issue

6

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25 February 2020

page(s)

831-837

1 reference

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

25 February 2020

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

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p53 mutant mice that display early ageing-associated phenotypes

7 April 2017

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Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.

28 September 2017

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Ageing populations: the challenges ahead

28 September 2017

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Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways

28 September 2017

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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

28 September 2017

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Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance

28 September 2017

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Cellular effects of long wavelength UV light (UVA) in mammalian cells

28 September 2017

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Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

28 September 2017

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Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan

28 September 2017

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Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross-sectional analyses of a large male and female population

28 September 2017

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Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis.

28 September 2017

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Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments

28 September 2017

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Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs

28 September 2017

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The structure and function of cartilage proteoglycans.

28 September 2017

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Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94.

28 September 2017

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What is intervertebral disc degeneration, and what causes it?

28 September 2017

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Animal models of osteoarthritis: lessons learned while seeking the "Holy Grail".

28 September 2017

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Clinical practice. Osteoarthritis of the knee

28 September 2017

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Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation

28 September 2017

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Vulnerability to ROS-induced cell death in ageing articular cartilage: the role of antioxidant enzyme activity.

28 September 2017

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Metabolism of the intervertebral disc: effects of low levels of oxygen, glucose, and pH on rates of energy metabolism of bovine nucleus pulposus cells

28 September 2017

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28 September 2017

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28 September 2017

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Aging theories of primary osteoarthritis: from epidemiology to molecular biology.

28 September 2017

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New pathways for reactive oxygen species generation in inflammation and potential novel pharmacological targets

28 September 2017

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Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro

28 September 2017

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A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice

28 September 2017

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The role of proteoglycans in aging, degeneration and repair of the intervertebral disc

28 September 2017

1 reference

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Roles of articular cartilage aging and chondrocyte senescence in the pathogenesis of osteoarthritis

28 September 2017

1 reference

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Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

28 September 2017

1 reference

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28 September 2017

1 reference

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31 May 2018

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Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science

31 May 2018

1 reference

Telomere erosion and senescence in human articular cartilage chondrocytes.

21 January 2018

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Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels

21 January 2018

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Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite

21 January 2018

1 reference

Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.

21 January 2018

1 reference

Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage

21 January 2018

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Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis

21 January 2018

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A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology

21 January 2018

1 reference

Accelerated, aging-dependent development of osteoarthritis in alpha1 integrin-deficient mice

21 January 2018

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A progeroid syndrome in mice is caused by defects in A-type lamins

21 January 2018

1 reference

Chondrocyte antioxidant defences: the roles of catalase and glutathione peroxidase in protection against H2O2 dependent inhibition of proteoglycan biosynthesis

21 January 2018

1 reference

12 December 2020

Mouse models of osteoarthritis provide new research tools

1 reference

12 December 2020

Modulation of intracellular reactive oxygen species level in chondrocytes by IGF-1, FGF, and TGF-beta1

1 reference

12 December 2020

Immunomorphological Analysis of RAGE Receptor Expression and NF- B Activation in Tissue Samples from Normal and Degenerated Intervertebral Discs of Various Ages

1 reference

12 December 2020

Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice

1 reference

12 December 2020

Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice

1 reference

12 December 2020

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12 December 2020

Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration

1 reference

12 December 2020

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12 December 2020

Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens

1 reference

12 December 2020

1 reference

12 December 2020

Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease

1 reference

12 December 2020

Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines

1 reference

12 December 2020

Effect of collagen turnover on the accumulation of advanced glycation end products

1 reference

12 December 2020

Stages in the natural history of the vertebral end-plates

1 reference

12 December 2020

Premature osteoarthritis in the Disproportionate micromelia (Dmm) mouse

1 reference

12 December 2020

Generation and use of transgenic mice as models of osteoarthritis

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12 December 2020

Biological theories of aging: an overview

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12 December 2020

Animal models of osteoarthritis

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12 December 2020

Identifiers

DOI

10.1002/JOR.22204

1 reference

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release_ercqoicuw5cfrkraabjpqff3vm

25 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ercqoicuw5cfrkraabjpqff3vm

24 November 2022

mapped directly with Wikidata item

2 references

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25 February 2020

PubMed publication ID

2 references

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