Catabolic and anabolic actions of parathyroid hormone on the skeleton (Q26828873)

Costa AG

2

1 reference

Cusano NE

3

1 reference

Kousteni S

4

1 reference

Bilezikian JP

5

1 reference

language of work or name

1 reference

November 2011

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Journal of Endocrinological Investigation

published in

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volume

34

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issue

10

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page(s)

801-10

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Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

7 April 2017

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A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery

7 April 2017

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Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

7 April 2017

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

7 April 2017

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Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

7 April 2017

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Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

7 April 2017

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

7 April 2017

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Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway

7 April 2017

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Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray

7 April 2017

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Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

7 April 2017

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G alpha(q) signal in osteoblasts is inhibitory to the osteoanabolic action of parathyroid hormone

7 April 2017

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PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.

28 September 2017

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Role of IGF-I on PTH effects on bone

28 September 2017

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Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model.

28 September 2017

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Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss

28 September 2017

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Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women

28 September 2017

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T cells: critical bone regulators in health and disease

28 September 2017

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Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Does osteocytic SOST suppression mediate PTH bone anabolism?

28 September 2017

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Parathyroid hormone suppresses osteoblast apoptosis by augmenting DNA repair

28 September 2017

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Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism

28 September 2017

1 reference

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PTH and PTHrP signaling in osteoblasts

28 September 2017

1 reference

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The cell biology of parathyroid hormone in osteoblasts

28 September 2017

1 reference

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T cells potentiate PTH-induced cortical bone loss through CD40L signaling

28 September 2017

1 reference

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Differentiation and proliferation of periosteal osteoblast progenitors are differentially regulated by estrogens and intermittent parathyroid hormone administration

28 September 2017

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The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years

28 September 2017

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The role of the receptor activator of nuclear factor-kappaB ligand/osteoprotegerin cytokine system in primary hyperparathyroidism

28 September 2017

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Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.

28 September 2017

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Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts

28 September 2017

1 reference

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Molecular and cellular mechanisms of the anabolic effect of intermittent PTH

28 September 2017

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Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism

28 September 2017

1 reference

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Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Skeletal actions of intermittent parathyroid hormone: effects on bone remodelling and structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Bone quality--the material and structural basis of bone strength and fragility

28 September 2017

1 reference

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Parathyroid hormone: past and present

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone as an anabolic skeletal therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

SOST is a target gene for PTH in bone

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone uses multiple mechanisms to arrest the cell cycle progression of osteoblastic cells from G1 to S phase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Bone strength in primary hyperparathyroidism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone and periosteal bone expansion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Involvement of osteoprotegerin/osteoclastogenesis inhibitory factor in the stimulation of osteoclast formation by parathyroid hormone in mouse bone cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells

28 September 2017

1 reference

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Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with parathyroid hormone and estradiol

28 September 2017

1 reference

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Osteoblastic cells mediate osteoclastic responsiveness to parathyroid hormone

28 September 2017

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The effects of calcium regulating hormones on bone resorption by isolated human osteoclastoma cells

28 September 2017

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28 September 2017

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Maintenance of cancellous bone connectivity in primary hyperparathyroidism: trabecular strut analysis

28 September 2017

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Back Pain and Vertebral Crush Fractures: An Unemphasized Mode of Presentation for Primary Hyperparathyroidism

28 September 2017

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Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS).

28 September 2017

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Short-term increases in bone turnover markers predict parathyroid hormone-induced spinal bone mineral density gains in postmenopausal women with glucocorticoid-induced osteoporosis

31 May 2018

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Vertebral osteopenia: a new indication for surgery in primary hyperparathyroidism.

31 May 2018

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Bone structure in postmenopausal hyperparathyroid, osteoporotic, and normal women

31 May 2018

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Mild asymptomatic primary hyperparathyroidism is not a risk factor for vertebral fractures.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Effects on bone geometry, density, and microarchitecture in the distal radius but not the tibia in women with primary hyperparathyroidism: A case-control study using HR-pQCT.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Effects of transient PTH on early proliferation, apoptosis, and subsequent differentiation of osteoblast in primary osteoblast cultures.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Treatment of postmenopausal osteoporotic women with parathyroid hormone 1-84 for 18 months increases cancellous bone formation and improves cancellous architecture: a study of iliac crest biopsies using histomorphometry and micro computed tomography

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy

28 November 2018

1 reference

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Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

PTH differentially regulates expression of RANKL and OPG.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Recombinant Human Parathyroid Hormone (1–34) [Teriparatide] Improves Both Cortical and Cancellous Bone Structure

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Intermittently administered human parathyroid hormone(1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

PTH/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4315330

Involvement of dual signal transduction systems in the stimulation of osteoclast-like cell formation by parathyroid hormone and parathyroid hormone-related peptide

28 November 2018

1 reference

12 December 2020

The risk of hip fractures in patients with primary hyperparathyroidism: a population-based cohort study with a follow-up of 19 years

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12 December 2020

Cancellous and cortical bone architecture and turnover at the iliac crest of postmenopausal osteoporotic women treated with parathyroid hormone 1-84

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12 December 2020

Patients with primary hyperparathyroidism have lower circulating sclerostin levels than euparathyroid controls

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12 December 2020

Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis

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12 December 2020

The Story of Hyperparathyroidism at the Massachusetts General Hospital

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12 December 2020

Skeletal disease in primary hyperparathyroidism

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12 December 2020

The histomorphometry of bone in primary hyperparathyroidism: preservation of cancellous bone structure

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12 December 2020

Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats

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12 December 2020

Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice

1 reference

12 December 2020

The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats

1 reference

12 December 2020

Marked improvement in bone mass after parathyroidectomy in osteitis fibrosa cystica

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12 December 2020

Primary hyperparathyroidism and the risk of fracture: a population-based study

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12 December 2020

Normal human osteoclasts formed from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts

1 reference

12 December 2020

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone

1 reference

12 December 2020

Microstructure of the trabecula and cortex of iliac bone in primary hyperparathyroidism patients determined using histomorphometry and node-strut analysis

1 reference

12 December 2020

Parathyroid hormone/parathyroid hormone-related peptide type 1 receptor in human bone

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12 December 2020

Catabolic effects of continuous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation

1 reference

12 December 2020

Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: a paired biopsy study

1 reference

12 December 2020

Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis

1 reference

12 December 2020

A comparative study of the bone-restorative efficacy of anabolic agents in aged ovariectomized rats

1 reference

12 December 2020

Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial

1 reference

12 December 2020