Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions (Q26830740)

Jamaica R. Rettberg

2

1 reference

Lauren P. Klosinski

3

1 reference

Enrique Cadenas

4

1 reference

Roberta Diaz Brinton

5

1 reference

language of work or name

1 reference

August 2011

1 reference

Molecular Aspects of Medicine

published in

1 reference

volume

32

1 reference

issue

4-6

1 reference

page(s)

247-57

1 reference

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

cites work

1 reference

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Regional aerobic glycolysis in the human brain

7 April 2017

1 reference

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Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition

7 April 2017

1 reference

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Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people

7 April 2017

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In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18)

7 April 2017

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11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment

7 April 2017

1 reference

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Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease

7 April 2017

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

7 April 2017

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2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

7 April 2017

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Fatty acid oxidation and ketogenesis by astrocytes in primary culture

7 April 2017

1 reference

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

7 April 2017

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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

7 April 2017

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

7 April 2017

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

7 April 2017

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

7 April 2017

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Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease

7 April 2017

1 reference

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Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease.

28 September 2017

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Amyloid-β-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway

28 September 2017

1 reference

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Mitochondria, Amyloid β, and Alzheimer's Disease

28 September 2017

1 reference

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Neuronal activity regulates the regional vulnerability to amyloid-β deposition

28 September 2017

1 reference

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Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes

28 September 2017

1 reference

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Lack of evidence for the efficacy of memantine in mild Alzheimer disease.

28 September 2017

1 reference

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The pathogenesis of Alzheimer's disease: a reevaluation of the "amyloid cascade hypothesis"

28 September 2017

1 reference

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Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling

28 September 2017

1 reference

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Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift

28 September 2017

1 reference

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Mitochondria: the common upstream driver of amyloid-β and tau pathology in Alzheimer's disease.

28 September 2017

1 reference

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Treatment with cholinesterase inhibitors and memantine of patients in the Alzheimer's Disease Neuroimaging Initiative

28 September 2017

1 reference

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Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative

28 September 2017

1 reference

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

28 September 2017

1 reference

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Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer's disease

28 September 2017

1 reference

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Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

28 September 2017

1 reference

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Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

28 September 2017

1 reference

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A mitocentric view of Alzheimer's disease suggests multi-faceted treatments

28 September 2017

1 reference

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Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects

28 September 2017

1 reference

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The Alzheimer's disease mitochondrial cascade hypothesis

28 September 2017

1 reference

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The mitochondrial secret(ase) of Alzheimer's disease

28 September 2017

1 reference

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Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease

28 September 2017

1 reference

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Can novel therapeutics halt the amyloid cascade?

28 September 2017

1 reference

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Membrane rafts in Alzheimer's disease beta-amyloid production

28 September 2017

1 reference

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White matter integrity and cortical metabolic associations in aging and dementia

28 September 2017

1 reference

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Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

28 September 2017

1 reference

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Mitochondria: a therapeutic target in neurodegeneration

28 September 2017

1 reference

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Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain

28 September 2017

1 reference

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Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease

28 September 2017

1 reference

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Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort

28 September 2017

1 reference

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

28 September 2017

1 reference

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The Alzheimer's disease mitochondrial cascade hypothesis: an update

28 September 2017

1 reference

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RNA oxidation in Alzheimer disease and related neurodegenerative disorders

28 September 2017

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FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease

28 September 2017

1 reference

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Reassessing the amyloid cascade hypothesis of Alzheimer's disease

28 September 2017

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Therapeutic potential of resveratrol in Alzheimer's disease

28 September 2017

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Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

28 September 2017

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Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease

28 September 2017

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Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease

28 September 2017

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Core candidate neurochemical and imaging biomarkers of Alzheimer's disease

28 September 2017

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Ketone bodies as a therapeutic for Alzheimer's disease

28 September 2017

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Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

28 September 2017

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Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease

28 September 2017

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3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease

28 September 2017

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Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

28 September 2017

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Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases

28 September 2017

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Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies

28 September 2017

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Hippocampal hypometabolism predicts cognitive decline from normal aging

28 September 2017

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Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease

28 September 2017

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Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

28 September 2017

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Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics

28 September 2017

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Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.

28 September 2017

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The key role of mitochondria in Alzheimer's disease

28 September 2017

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Neuron-glia metabolic coupling and plasticity

28 September 2017

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Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

28 September 2017

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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

28 September 2017

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Mitochondria take center stage in aging and neurodegeneration

28 September 2017

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Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

28 September 2017

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Cerebral ketone body metabolism

28 September 2017

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A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease

28 September 2017

1 reference

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Ketone body synthesis in the brain: possible neuroprotective effects

28 September 2017

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CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease

28 September 2017

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Alzheimer's disease and the amyloid cascade hypothesis: ten years on.

28 September 2017

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Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET).

28 September 2017

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The mitochondrial spiral. An adequate cause of dementia in the Alzheimer's syndrome.

28 September 2017

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Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways

28 September 2017

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Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

28 September 2017

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Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

31 May 2018

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Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease

31 May 2018

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Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

31 May 2018

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Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

31 May 2018

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Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases

31 May 2018

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31 May 2018

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Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease

31 May 2018

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28 November 2018

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Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c.

28 November 2018

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28 November 2018

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28 November 2018

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Whole brain atrophy rate predicts progression from MCI to Alzheimer's disease

28 November 2018

1 reference

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Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.

28 November 2018

1 reference

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Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

28 November 2018

1 reference

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Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates

28 November 2018

1 reference

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Brain imaging evidence of preclinical Alzheimer's disease in normal aging

28 November 2018

1 reference

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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

28 November 2018

1 reference

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ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction

28 November 2018

1 reference

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Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

28 November 2018

1 reference

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Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Neuropathology of cognitively normal elderly

28 November 2018

1 reference

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Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?

28 November 2018

1 reference

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Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease.

28 November 2018

1 reference

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Statin therapy for Alzheimer's disease: will it work?

28 November 2018

1 reference

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Alzheimer's disease: molecular concepts and therapeutic targets

28 November 2018

1 reference

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Oxidative damage is the earliest event in Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Hippocampal formation glucose metabolism and volume losses in MCI and AD.

28 November 2018

1 reference

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Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

28 November 2018

1 reference

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Functional mitochondria are required for amyloid beta-mediated neurotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

28 November 2018

1 reference

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Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Respiratory chain enzyme activities in isolated mitochondria of lymphocytes from patients with Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3658304

Cytochrome oxidase deficiency in Alzheimer's disease

28 November 2018

1 reference

12 December 2020

Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group

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12 December 2020

[11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease

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12 December 2020

Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance

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12 December 2020

Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia

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12 December 2020

10.1016/J.MAM.2011.10.005

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

22024249

1 reference