A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation (Q26850196)

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English	A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation	scientific article

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scholarly article

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A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation (English)

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Heart failure with preserved ejection fraction

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ejection fraction

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author name string

Walter J. Paulus

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Carsten Tschöpe

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language of work or name

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publication date

23 July 2013

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Journal of the American College of Cardiology

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62

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263-71

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4

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Heart failure with preserved ejection fraction: treat now by treating comorbidities

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Contribution of comorbidities to functional impairment is higher in heart failure with preserved than with reduced ejection fraction

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Left ventricular adaptation to chronic pressure overload induced by inhibition of nitric oxide synthase in rats

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Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

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ACE inhibition and endothelial function: main findings of PERFECT, a sub-study of the EUROPA trial

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Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure

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Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension.

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Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)

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Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction

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The role of leukocyte-generated oxidants in left ventricular remodeling

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Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials

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Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial.

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Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database.

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Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy

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Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.

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Treatment of heart failure with normal ejection fraction: an inconvenient truth!

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The aging process of the heart: obesity is the main risk factor for left atrial enlargement during aging the MONICA/KORA (monitoring of trends and determinations in cardiovascular disease/cooperative research in the region of Augsburg) study

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Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study

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Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction

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7 January 2021

based on heuristic

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Pentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction

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Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction.

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Tachycardia-induced diastolic dysfunction and resting tone in myocardium from patients with a normal ejection fraction

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Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study.

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New targets to treat the structural remodeling of the myocardium

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7 January 2021

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Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry

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Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy

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7 January 2021

based on heuristic

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Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.

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Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction

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What have we learned about patients with heart failure and preserved ejection fraction from DIG-PEF, CHARM-preserved, and I-PRESERVE?

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Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction

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7 January 2021

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Endothelial dysfunction: a pathophysiologic factor in heart failure with preserved ejection fraction

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Peroxynitrite Increases Protein Phosphatase Activity and Promotes the Interaction of Phospholamban with Protein Phosphatase 2a in the Myocardium.

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Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).

1 reference

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Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

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The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.

1 reference

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The role of nitric oxide in the failing heart

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The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling

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based on heuristic

inferred from DOI database lookup

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

1 reference

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based on heuristic

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Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study

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Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators

1 reference

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based on heuristic

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Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle

1 reference

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7 January 2021

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Combination of isosorbide dinitrate and hydralazine in blacks with heart failure

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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Understanding "diastolic" heart failure

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based on heuristic

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Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Autophagy, redox signaling, and ventricular remodeling

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based on heuristic

inferred from DOI database lookup

Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure

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Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community

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7 January 2021

based on heuristic

inferred from DOI database lookup

Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?

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based on heuristic

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Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency

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7 January 2021

based on heuristic

inferred from DOI database lookup

Haemodynamic, neuroendocrine and metabolic correlates of circulating cytokine concentrations in congestive heart failure

1 reference

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Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease

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based on heuristic

inferred from DOI database lookup

Inflammation and metabolic dysfunction: links to cardiovascular diseases

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between oxidative stress and inflammation in salt-sensitive hypertension.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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Cardiomyocyte Stiffness in Diastolic Heart Failure

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7 January 2021

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High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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Load versus humoral activation in the genesis of early hypertensive heart disease

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7 January 2021

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7 January 2021

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Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction.

1 reference

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7 January 2021

based on heuristic

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PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study.

1 reference

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inferred from DOI database lookup

Clinical characteristics of pulmonary hypertension in patients with heart failure and preserved ejection fraction.

1 reference

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7 January 2021

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1 reference

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7 January 2021

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inferred from DOI database lookup

Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction: findings from the I-PRESERVE trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness

1 reference

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7 January 2021

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Statin therapy may be associated with lower mortality in patients with diastolic heart failure: a preliminary report

1 reference

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7 January 2021

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Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

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Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation

1 reference

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7 January 2021

based on heuristic

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Diastolic Stiffness of the Failing Diabetic Heart

1 reference

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based on heuristic

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Heart failure with preserved and reduced left ventricular ejection fraction in the antihypertensive and lipid-lowering treatment to prevent heart attack trial

1 reference

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Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension.

1 reference

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7 January 2021

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The progression of hypertensive heart disease

1 reference

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7 January 2021

based on heuristic

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Passive stiffness of myocardium from congenital heart disease and implications for diastole.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cardiac titin: a multifunctional giant

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

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Vascular inflammation in obesity and sleep apnea

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Circulating biomarkers of collagen metabolism in cardiac diseases

1 reference

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7 January 2021

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Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients With Heart Failure and a Preserved Ejection Fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Long-term follow-up of participants with heart failure in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT).

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus

1 reference

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7 January 2021

based on heuristic

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Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community

1 reference

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7 January 2021

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Pulmonary hypertension in heart failure with preserved ejection fraction: a target of phosphodiesterase-5 inhibition in a 1-year study

1 reference

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7 January 2021

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Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling

1 reference

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7 January 2021

based on heuristic

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Obesity and cardiovascular disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes.

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Low-sodium dietary approaches to stop hypertension diet reduces blood pressure, arterial stiffness, and oxidative stress in hypertensive heart failure with preserved ejection fraction

1 reference

https://api.crossref.org/works/10.1016%2FJ.JACC.2013.02.092

7 January 2021

based on heuristic

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Oxidative stress and apoptosis in heart failure progression

1 reference

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7 January 2021

based on heuristic

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Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts

1 reference

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7 January 2021

based on heuristic

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Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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