Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy (Q45235067)

11 December 2017

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy (English)

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11 December 2017

9

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11 December 2017

Eiki Takimoto

1

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11 December 2017

Hunter C Champion

2

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11 December 2017

Manxiang Li

3

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11 December 2017

Diego Belardi

4

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11 December 2017

Shuxun Ren

5

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11 December 2017

E Rene Rodriguez

6

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11 December 2017

Djahida Bedja

7

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11 December 2017

Kathleen L Gabrielson

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11 December 2017

David A Kass

10

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11 December 2017

language of work or name

English

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publication date

23 January 2005

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11 December 2017

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11

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214-222

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2

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https://scigraph.springernature.com/pub.10.1038/nm1175

11 December 2017

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cites work

Cardiac hypertrophy: the good, the bad, and the ugly

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Hypertrophy of the heart: a new therapeutic target?

21 January 2018

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Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice

21 January 2018

1 reference

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

21 January 2018

1 reference

A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy

21 January 2018

1 reference

Expression of constitutively active guanylate cyclase in cardiomyocytes inhibits the hypertrophic effects of isoproterenol and aortic constriction on mouse hearts.

21 January 2018

1 reference

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

21 January 2018

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Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes.

21 January 2018

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Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice

21 January 2018

1 reference

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

21 January 2018

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Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease

21 January 2018

1 reference

Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group

21 January 2018

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Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study

21 January 2018

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Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure

21 January 2018

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cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism

21 January 2018

1 reference

Sildenafil citrate does not affect cardiac contractility in human or dog heart

21 January 2018

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

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Time-dependent systolic and diastolic function in mice overexpressing calcineurin

21 January 2018

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Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death

21 January 2018

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MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq.

21 January 2018

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Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin

21 January 2018

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The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

21 January 2018

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

21 January 2018

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Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

21 January 2018

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

21 January 2018

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

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Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.

21 January 2018

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Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

21 January 2018

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A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta

21 January 2018

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Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts

21 January 2018

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Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

21 January 2018

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Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat

21 January 2018

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PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

21 January 2018

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Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity

21 January 2018

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Nitric oxide and cardiac function: ten years after, and continuing

21 January 2018

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Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3.

21 January 2018

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Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.

21 January 2018

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Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

21 January 2018

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cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5

21 January 2018

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Regulation of gene expression by cyclic GMP.

21 January 2018

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Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

21 January 2018

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Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.

21 January 2018

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Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

21 January 2018

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Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.

21 January 2018

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Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells

21 January 2018

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Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

21 January 2018

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Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NM1175

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Dimensions Publication ID

11 December 2017

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