Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies (Q26861683)

Carlo Ballatore

2

1 reference

Virginia M.-Y. Lee

3

1 reference

Amos B. Smith

4

1 reference

John Q. Trojanowski

5

1 reference

language of work or name

1 reference

August 2012

1 reference

Biochemical Society Transactions

published in

1 reference

volume

40

1 reference

issue

4

1 reference

page(s)

661-6

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Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease

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Differential regulation of dynein and kinesin motor proteins by tau

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7 April 2017

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The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

7 April 2017

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The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies

28 September 2017

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Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

28 September 2017

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Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies

28 September 2017

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Novel microtubule-targeting agents - the epothilones.

28 September 2017

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Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

28 September 2017

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Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments

28 September 2017

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Design, synthesis, and biological evaluation of new-generation taxoids

28 September 2017

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Targeting the microtubules in breast cancer beyond taxanes: the epothilones

28 September 2017

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Multiple-motor based transport and its regulation by Tau.

28 September 2017

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Biochemistry and molecular biology of tauopathies

28 September 2017

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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

28 September 2017

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Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro

28 September 2017

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Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease

28 September 2017

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Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation

28 September 2017

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Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation

28 September 2017

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

28 September 2017

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Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

28 September 2017

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Microtubule stabilizing drugs for the treatment of Alzheimer's disease

28 September 2017

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

28 September 2017

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Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

28 September 2017

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Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies

28 September 2017

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Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

31 May 2018

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31 May 2018

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31 May 2018

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Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)

21 January 2018

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Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

31 May 2018

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Structure and novel exons of the human tau gene

31 May 2018

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Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

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21 January 2018

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Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

21 January 2018

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

21 January 2018

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Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo

21 January 2018

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Chemical modification of paclitaxel (Taxol) reduces P-glycoprotein interactions and increases permeation across the blood-brain barrier in vitro and in situ

21 January 2018

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Tau interaction with microtubules in vivo

21 January 2018

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Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22817712

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Domains of tau protein and interactions with microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/22817712

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22817712

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BST20120010

1 reference

1 reference

1 reference

PubMed publication ID

22817712

1 reference