Tau-mediated neurodegeneration in Alzheimer's disease and related disorders (Q29618148)

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3 January 2020

review article

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title

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders (English)

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30 April 2017

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3 January 2020

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1

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3 January 2020

3

John Q Trojanowski

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3 January 2020

author name string

Virginia M-Y Lee

series ordinal

2

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language of work or name

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30 April 2017

publication date

1 September 2007

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Nature Reviews Neuroscience

3 January 2020

published in

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30 April 2017

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3 January 2020

volume

8

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30 April 2017

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3 January 2020

page(s)

663-672

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3 January 2020

issue

9

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30 April 2017

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Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

3 January 2020

cites work

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Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

1 May 2017

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Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

1 May 2017

1 reference

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 May 2017

1 reference

Axonal transport defects: a common theme in neurodegenerative diseases

1 May 2017

1 reference

Protein aggregation and neurodegenerative disease

1 May 2017

1 reference

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 May 2017

1 reference

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 May 2017

1 reference

Tau suppression in a neurodegenerative mouse model improves memory function

1 May 2017

1 reference

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 May 2017

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Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

1 May 2017

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The blood-brain barrier: bottleneck in brain drug development

1 May 2017

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

1 May 2017

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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

31 March 2020

1 reference

Tau and src family tyrosine kinases

31 March 2020

1 reference

The microtubule binding domain of tau protein.

31 March 2020

1 reference

The distribution of tau in the mammalian central nervous system

31 March 2020

1 reference

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

31 March 2020

1 reference

Microtubule structure and its stabilisation

31 March 2020

1 reference

Discodermolide interferes with the binding of tau protein to microtubules.

31 March 2020

1 reference

Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease

31 March 2020

1 reference

Evaluating triggers and enhancers of tau fibrillization.

31 March 2020

1 reference

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

31 March 2020

1 reference

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

31 March 2020

1 reference

Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.

31 March 2020

1 reference

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

31 March 2020

1 reference

Post-translational modifications of tau protein in Alzheimer's disease

31 March 2020

1 reference

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

31 March 2020

1 reference

Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

31 March 2020

1 reference

SUMO on the road to neurodegeneration

31 March 2020

1 reference

Tau phosphorylation and proteolysis: insights and perspectives.

31 March 2020

1 reference

Pathways of tau fibrillization.

31 March 2020

1 reference

Granular tau oligomers as intermediates of tau filaments

31 March 2020

1 reference

Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

31 March 2020

1 reference

Mutations causing neurodegenerative tauopathies

31 March 2020

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Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

31 March 2020

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Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

31 March 2020

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Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

31 March 2020

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Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

31 March 2020

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Tau therapeutic strategies for the treatment of Alzheimer's disease

31 March 2020

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

31 March 2020

1 reference

Role of serine/threonine protein phosphatase in Alzheimer's disease

31 March 2020

1 reference

Oxidative stress in neurodegeneration: cause or consequence?

31 March 2020

1 reference

Oxidative stress and neurodegeneration

31 March 2020

1 reference

Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid

31 March 2020

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Tau is essential to beta -amyloid-induced neurotoxicity

31 March 2020

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Tau modifiers as therapeutic targets for Alzheimer's disease

31 March 2020

1 reference

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

31 March 2020

1 reference

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

31 March 2020

1 reference

Pathways by which Abeta facilitates tau pathology

31 March 2020

1 reference

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

31 March 2020

1 reference

Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.

31 March 2020

1 reference

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

31 March 2020

1 reference

Overview of Protein Aggregation in Single, Double, and Triple Neurodegenerative Brain Amyloidoses

31 March 2020

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Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment

31 March 2020

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Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.

31 March 2020

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

31 March 2020

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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

31 March 2020

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

31 March 2020

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Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

31 March 2020

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Pathological tau: a loss of normal function or a gain in toxicity?

31 March 2020

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Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

31 March 2020

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Transgenic animal models of tauopathies

31 March 2020

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Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics

31 March 2020

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Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases

31 March 2020

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Screening for inhibitors of tau polymerization

31 March 2020

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Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

31 March 2020

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Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

31 March 2020

1 reference

Congo red and protein aggregation in neurodegenerative diseases

31 March 2020

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Ligand-dependent inhibition and reversal of tau filament formation

31 March 2020

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Development of a fluorescent high throughput assay for tau aggregation

31 March 2020

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Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant

31 March 2020

1 reference

A decade of tau transgenic animal models and beyond

31 March 2020

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A decade of modeling Alzheimer's disease in transgenic mice.

31 March 2020

1 reference

Drug discovery in dementia: the role of rodent models

31 March 2020

1 reference

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

31 March 2020

1 reference

Therapies for Alzheimer's disease.

31 March 2020

1 reference

Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.

31 March 2020

1 reference

Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein

31 March 2020

1 reference

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

31 March 2020

1 reference

Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice

31 March 2020

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

31 March 2020

1 reference

Tau filament formation in transgenic mice expressing P301L tau.

31 March 2020

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Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

31 March 2020

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Oligodendroglial tau filament formation in transgenic mice expressing G272V tau.

31 March 2020

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Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

31 March 2020

1 reference

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

31 March 2020

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Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.

31 March 2020

1 reference

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.

31 March 2020

1 reference

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

31 March 2020

1 reference

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

31 March 2020

1 reference

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

31 March 2020

1 reference

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

31 March 2020

1 reference

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

31 March 2020

1 reference

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

31 March 2020

1 reference

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

31 March 2020

1 reference

31 March 2020

CHIP-ping away at tau.

1 reference

Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

31 March 2020

1 reference

Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs

31 March 2020

1 reference

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31 March 2020

Identifiers

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

3 January 2020

1032680057

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115175

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

115175

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17684513%20AND%20SRC:MED&resulttype=core&format=json