Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models (Q26863375)

Crossref

J. Timothy Greenamyre

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

September 2013

1 reference

published in

Neurobiology of Disease

1 reference

volume

57

1 reference

page(s)

38-46

1 reference

Rotenone, paraquat, and Parkinson's disease

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Multiple roles for nicotine in Parkinson's disease

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Pesticide/environmental exposures and Parkinson's disease in East Texas

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Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity

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The blood-brain barrier: bottleneck in brain drug development

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 March 2017

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Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

21 March 2017

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Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results

21 March 2017

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Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease

21 March 2017

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 March 2017

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Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression

21 March 2017

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A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease

21 March 2017

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 March 2017

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Aging produces a specific pattern of striatal dopamine loss: implications for the etiology of idiopathic Parkinson's disease

21 March 2017

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Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts

21 March 2017

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

21 March 2017

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 March 2017

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Epidemiology of Parkinson's disease

7 April 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 April 2017

1 reference

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Association between early-onset Parkinson's disease and mutations in the parkin gene

7 April 2017

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Ageing and Parkinson's disease: substantia nigra regional selectivity

7 April 2017

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Mitochondrial pathology in Parkinson's disease

7 April 2017

1 reference

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The role of environmental exposures in neurodegeneration and neurodegenerative diseases

28 September 2017

1 reference

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Epidemiology and etiology of Parkinson's disease: a review of the evidence

28 September 2017

1 reference

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Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

28 September 2017

1 reference

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The genetics of Parkinson disease

28 September 2017

1 reference

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Neurotoxic in vivo models of Parkinson's disease recent advances.

28 September 2017

1 reference

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α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease

28 September 2017

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Well-water consumption and Parkinson's disease in rural California

28 September 2017

1 reference

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Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

28 September 2017

1 reference

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Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats

28 September 2017

1 reference

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Dopamine transporter genetic variants and pesticides in Parkinson's disease

28 September 2017

1 reference

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The paradoxical cell biology of alpha-Synucle

28 September 2017

1 reference

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A highly reproducible rotenone model of Parkinson's disease

28 September 2017

1 reference

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Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

28 September 2017

1 reference

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Epidemiologic studies of environmental exposures in Parkinson's disease

28 September 2017

1 reference

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MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

G2019S LRRK2 mutation in French and North African families with Parkinson's disease

28 September 2017

1 reference

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Pesticides and risk of Parkinson disease: a population-based case-control study

28 September 2017

1 reference

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Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity

28 September 2017

1 reference

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Strong association between N-acetyltransferase 2 genotype and PD in Hong Kong Chinese

28 September 2017

1 reference

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

28 September 2017

1 reference

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The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.

28 September 2017

1 reference

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Variability and validity of polymorphism association studies in Parkinson's disease

28 September 2017

1 reference

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Neuropathology of Parkinson's disease

28 September 2017

1 reference

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

28 September 2017

1 reference

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

28 September 2017

1 reference

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Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

28 September 2017

1 reference

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Parkinson's disease: a case-control study of occupational and environmental risk factors.

28 September 2017

1 reference

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Features of the dopaminergic neurotoxin MPTP.

28 September 2017

1 reference

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DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.

31 May 2018

1 reference

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DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

31 May 2018

1 reference

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Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss

31 May 2018

1 reference

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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Incidence and risk factors of Parkinson's disease in The Netherlands.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Expression of multi-drug resistance 1 mRNA in human and rodent tissues: reduced levels in Parkinson patients

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

-Synuclein, pesticides, and Parkinson disease: A case-control study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Effect of MDR1 haplotype on risk of Parkinson disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Blood-brain barrier dysfunction in parkinsonian midbrain in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

MDR1, the blood-brain barrier transporter, is associated with Parkinson's disease in ethnic Chinese

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Parkin mutations are frequent in patients with isolated early-onset parkinsonism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Poor metabolization of n-hexane in Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathology.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Familial Aggregation of Parkinson's Disease in Iceland

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

A transcription-activating polymorphism in the ACHE promoter associated with acute sensitivity to anti-acetylcholinesterases.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Variations in the monoamine oxidase B (MAOB) gene are associated with Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Transient severe parkinsonism after acute organophosphate poisoning

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Gene-toxin interaction as a putative risk factor for Parkinson's disease with dementia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Environmental risk factors and Parkinson's disease: a case-control study in Taiwan

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Epidemiologic observations on Parkinson's disease: incidence and mortality in a prospective study of middle-aged men.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Extrapyramidal manifestations complicating organophosphorus insecticide poisoning

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

Acute organophosphate poisoning presenting with choreo-athetosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3815566

5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study

28 November 2018

1 reference

12 December 2020

Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease

1 reference

12 December 2020

Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease?

1 reference

12 December 2020

A meta-analysis of Parkinson's disease and exposure to pesticides

1 reference

12 December 2020

Paraoxonase 1 Met--Leu 54 polymorphism is associated with Parkinson's disease

1 reference

12 December 2020

MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD

1 reference

12 December 2020

Familial aggregation of early- and late-onset Parkinson's disease

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

12 December 2020

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

1 reference

12 December 2020

Mutant debrisoquine hydroxylation genes in Parkinson's disease

1 reference

12 December 2020

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1 reference

12 December 2020

Association of a monoamine oxidase B allele with Parkinson's disease

1 reference

12 December 2020

A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease

1 reference

12 December 2020

Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease

1 reference

12 December 2020

Hereditary variations in monoamine oxidase as a risk factor for Parkinson's disease

1 reference

12 December 2020

Identification of catechol-protein conjugates in neostriatal slices incubated with [3H]dopamine: impact of ascorbic acid and glutathione

1 reference

12 December 2020

An allelic association study of monoamine oxidase B in Parkinson's disease

1 reference

12 December 2020

Association between the oxidative polymorphism and early onset of Parkinson's disease

1 reference

12 December 2020

The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988-1993

1 reference

12 December 2020

Association analysis of a polymorphism of the monoamine oxidase B gene with Parkinson's disease in a Japanese population

1 reference

12 December 2020

No association between Parkinson's disease and monoamine oxidase A and B gene polymorphisms.

1 reference

12 December 2020

Association of a polymorphism in intron 13 of the monoamine oxidase B gene with Parkinson disease.

1 reference

12 December 2020

1 reference

12 December 2020

Case-control study of interactions between genetic and environmental factors in Parkinson's disease

1 reference

12 December 2020

Association of N-acetyl transferase 2 gene polymorphism and slow acetylator phenotype with young onset and late onset Parkinson's disease among Indians

1 reference

12 December 2020

10.1016/J.NBD.2012.06.025

Identifiers

DOI

1 reference

release_mpznlldx4jf5vl4dknww3bdzla

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

22776331

1 reference