Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function (Q46797053)

25 December 2017

title

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function (English)

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25 December 2017

13

Ted M Dawson

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25 December 2017

Cheng Wang

1

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25 December 2017

Han Seok Ko

2

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25 December 2017

Bobby Thomas

3

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25 December 2017

Fai Tsang

4

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25 December 2017

Katherine C M Chew

5

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25 December 2017

Shiam-Peng Tay

6

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25 December 2017

Michelle W L Ho

7

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25 December 2017

Tit-Meng Lim

8

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25 December 2017

Tuck-Wah Soong

9

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25 December 2017

Olga Pletnikova

10

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25 December 2017

Juan Troncoso

11

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25 December 2017

Valina L Dawson

12

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25 December 2017

Kah-Leong Lim

14

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25 December 2017

publication date

8 November 2005

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25 December 2017

published in

Human Molecular Genetics

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25 December 2017

volume

14

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25 December 2017

issue

24

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25 December 2017

page(s)

3885-3897

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

cites work

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Molecular pathophysiology of Parkinson's disease

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How do Parkin mutations result in neurodegeneration?

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Parkin genetics: one model for Parkinson's disease

21 January 2018

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Functional association of the parkin gene promoter with idiopathic Parkinson's disease

21 January 2018

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Parkin attenuates manganese-induced dopaminergic cell death

21 January 2018

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

21 January 2018

1 reference

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

21 January 2018

1 reference

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Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

21 January 2018

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Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents

21 January 2018

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Environmental factors in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Redox redux: revisiting PTPs and the control of cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI413

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI413

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25 December 2017

PubMed ID

16278233

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25 December 2017