Immune checkpoint blockade in hepatocellular carcinoma: current progress and future directions (Q26865859)

main subject

hepatocellular carcinoma

1 reference

Tai Hato

1

1 reference

Lipika Goyal

2

1 reference

Tim F. Greten

3

1 reference

Dan G. Duda

4

1 reference

Andrew X. Zhu

5

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language of work or name

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November 2014

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1 reference

60

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issue

5

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page(s)

1776-82

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Molecular mechanisms of T cell co-stimulation and co-inhibition

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Human CD14+ CTLA-4+ regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma.

28 September 2017

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Strength of PD-1 signaling differentially affects T-cell effector functions.

28 September 2017

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Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance

28 September 2017

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Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality

28 September 2017

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Selective recruitment of regulatory T cell through CCR6-CCL20 in hepatocellular carcinoma fosters tumor progression and predicts poor prognosis

28 September 2017

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Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma

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28 September 2017

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28 September 2017

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28 September 2017

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Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

28 September 2017

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Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor.

28 September 2017

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The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression

28 September 2017

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Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets.

28 September 2017

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Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma

28 September 2017

1 reference

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Inhibitory B7-family molecules in the tumour microenvironment

28 September 2017

1 reference

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A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells

28 September 2017

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Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies

28 September 2017

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PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

28 September 2017

1 reference

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Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma

28 September 2017

1 reference

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Spontaneous tumor-specific humoral and cellular immune responses to NY-ESO-1 in hepatocellular carcinoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211962

PD-1 inhibits antiviral immunity at the effector phase in the liver

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211962

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211962

Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211962

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

28 September 2017

1 reference

Prospective randomized controlled trial comparing percutaneous acetic acid injection and percutaneous ethanol injection for small hepatocellular carcinoma.

21 January 2018

1 reference

Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.

21 January 2018

1 reference

Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis.

21 January 2018

1 reference

Analysis of CD4+ T-Cell Responses to a Novel -Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients

21 January 2018

1 reference

Lack of ex vivo peripheral and intrahepatic α-fetoprotein-specific CD4+ responses in hepatocellular carcinoma.

21 January 2018

1 reference

Intratumoural GM-CSF microspheres and CTLA-4 blockade enhance the antitumour immunity induced by thermal ablation in a subcutaneous murine hepatoma model

21 January 2018

1 reference

Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer

21 January 2018

1 reference

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.

21 January 2018

1 reference

The interaction properties of costimulatory molecules revisited.

21 January 2018

1 reference

CTLA-4-Ig regulates tryptophan catabolism in vivo.

21 January 2018

1 reference

Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial

21 January 2018

1 reference

Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma

21 January 2018

1 reference

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

21 January 2018

1 reference

PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211962

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4211962

Foxp3-dependent programme of regulatory T-cell differentiation

28 November 2018

1 reference

Percutaneous ethanol injection therapy for hepatocellular carcinoma. A histopathologic study

21 January 2018

1 reference

12 December 2020

Kupffer cells required for high affinity peptide-induced deletion, not retention, of activated CD8+ T cells by mouse liver

1 reference

12 December 2020

Low-dose cyclophosphamide treatment impairs regulatory T cells and unmasks AFP-specific CD4+ T-cell responses in patients with advanced HCC

1 reference

12 December 2020

Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy

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12 December 2020

Identifiers

DOI

10.1002/HEP.27246

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PubMed publication ID

24912948

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