Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease (Q26995351)

David T. Dexter

series ordinal

2

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language of work or name

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April 2014

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Journal of Neurochemistry

published in

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volume

129

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issue

1

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page(s)

4-20

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Alternative excitotoxic hypotheses

cites work

1 reference

The functional anatomy of basal ganglia disorders

21 January 2018

1 reference

Group III and subtype 4 metabotropic glutamate receptor agonists: discovery and pathophysiological applications in Parkinson's disease

21 January 2018

1 reference

Oxidative stress in neurodegeneration: cause or consequence?

21 January 2018

1 reference

Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins

21 January 2018

1 reference

Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease

21 January 2018

1 reference

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function.

21 January 2018

1 reference

Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation.

21 January 2018

1 reference

Neurodegenerative diseases and oxidative stress

21 January 2018

1 reference

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

21 January 2018

1 reference

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

21 January 2018

1 reference

Metabotropic glutamate receptors: synaptic modulators and therapeutic targets for neurologic disease

21 January 2018

1 reference

Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia

21 January 2018

1 reference

Macrophage polarization in bacterial infections

21 January 2018

1 reference

Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease

21 January 2018

1 reference

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

21 January 2018

1 reference

Blockade of subthalamic glutamatergic activity corrects changes in neuronal metabolism and motor behavior in rats with nigrostriatal lesions.

21 January 2018

1 reference

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

21 January 2018

1 reference

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

21 January 2018

1 reference

Distribution of group III mGluRs in rat basal ganglia with subtype-specific antibodies

21 January 2018

1 reference

Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata

21 January 2018

1 reference

Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures

21 January 2018

1 reference

3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists

21 January 2018

1 reference

Regulation of neurotransmitter release by metabotropic glutamate receptors

21 January 2018

1 reference

Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders

21 January 2018

1 reference

Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

21 January 2018

1 reference

PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP.

21 January 2018

1 reference

Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

1 reference

Metabotropic glutamate receptors in the basal ganglia motor circuit

21 January 2018

1 reference

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

21 January 2018

1 reference

Microglia and neurodegeneration: the role of systemic inflammation.

21 January 2018

1 reference

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

21 January 2018

1 reference

Differential localization of metabotropic glutamate receptors during postnatal development

21 January 2018

1 reference

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

21 January 2018

1 reference

Excitotoxic injury of the neostriatum: a model for Huntington's disease

21 January 2018

1 reference

System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.

21 January 2018

1 reference

Acute pharmacological modulation of mGluR8 reduces measures of anxiety

21 January 2018

1 reference

Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges

21 January 2018

1 reference

An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction

21 January 2018

1 reference

Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders

21 January 2018

1 reference

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

21 January 2018

1 reference

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

21 January 2018

1 reference

Neuroprotective effects of group III mGluR in traumatic neuronal injury

21 January 2018

1 reference

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

21 January 2018

1 reference

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

21 January 2018

1 reference

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

21 January 2018

1 reference

Metabotropic glutamate receptors.

21 January 2018

1 reference

Orthosteric versus allosteric GPCR activation: the great challenge of group-III mGluRs

21 January 2018

1 reference

Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis

21 January 2018

1 reference

Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer's disease

21 January 2018

1 reference

Riluzole enhances glutamate uptake in rat astrocyte cultures

21 January 2018

1 reference

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

21 January 2018

1 reference

Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.

21 January 2018

1 reference

Mechanisms underlying inflammation in neurodegeneration

21 January 2018

1 reference

Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity.

21 January 2018

1 reference

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

21 January 2018

1 reference

Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.

21 January 2018

1 reference

Differential regulation by protein kinases of activity and cell surface expression of glutamate transporters in neuron-enriched cultures

21 January 2018

1 reference

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

21 January 2018

1 reference

Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons.

21 January 2018

1 reference

Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice

21 January 2018

1 reference

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

21 January 2018

1 reference

Therapeutic potential of metabotropic glutamate receptor modulators

21 January 2018

1 reference

21 January 2018

1 reference

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways

21 January 2018

1 reference

Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

21 January 2018

1 reference

Glutamate receptor subunit expression in primary neuronal and secondary glial cultures

21 January 2018

1 reference

Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.

21 January 2018

1 reference

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

21 January 2018

1 reference

4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators

21 January 2018

1 reference

The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

21 January 2018

1 reference

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recept

21 January 2018

1 reference

The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

21 January 2018

1 reference

ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization

21 January 2018

1 reference

Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats

21 January 2018

1 reference

Multiple sclerosis and glutamate excitotoxicity.

21 January 2018

1 reference

Microglia: a sensor for pathological events in the CNS

21 January 2018

1 reference

Cortical demyelination and diffuse white matter injury in multiple sclerosis.

21 January 2018

1 reference

NMDA-dependent superoxide production and neurotoxicity

21 January 2018

1 reference

Glutamate receptors, neurotoxicity and neurodegeneration

21 January 2018

1 reference

A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease

21 January 2018

1 reference

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.

21 January 2018

1 reference

Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway

21 January 2018

1 reference

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

21 January 2018

1 reference

Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

21 January 2018

1 reference

Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease

21 January 2018

1 reference

Functional interaction between adenosine A2A and group III metabotropic glutamate receptors to reduce parkinsonian symptoms in rats.

21 January 2018

1 reference

Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity

21 January 2018

1 reference

Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo.

21 January 2018

1 reference

Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat.

21 January 2018

1 reference

Therapeutic promise and principles: metabotropic glutamate receptors

21 January 2018

1 reference

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

21 January 2018

1 reference

Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease

21 January 2018

1 reference

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

21 January 2018

1 reference

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease.

21 January 2018

1 reference

Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction

21 January 2018

1 reference

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

21 January 2018

1 reference

Inflammatory processes in amyotrophic lateral sclerosis

21 January 2018

1 reference

Metabotropic glutamate receptors inhibit microglial glutamate release.

21 January 2018

1 reference

Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning

21 January 2018

1 reference

Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract

21 January 2018

1 reference

A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo

21 January 2018

1 reference

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

21 January 2018

1 reference

Neuroinflammation in Huntington's disease

21 January 2018

1 reference

A pilot study of N-methyl-D-aspartate (NMDA) antagonist in Parkinson's disease

21 January 2018

1 reference

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists

21 January 2018

1 reference

Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

21 January 2018

1 reference

Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration

21 January 2018

1 reference

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

21 January 2018

1 reference

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

21 January 2018

1 reference

Metabotropic glutamate receptors: physiology, pharmacology, and disease

21 January 2018

1 reference

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

21 January 2018

1 reference

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

21 January 2018

1 reference

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

21 January 2018

1 reference

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

21 January 2018

1 reference

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats.

21 January 2018

1 reference

Peripheral administration of group III mGlu receptor agonist ACPT-I exerts potential antipsychotic effects in rodents

21 January 2018

1 reference

The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent

21 January 2018

1 reference

IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice

21 January 2018

1 reference

mGluR7 is a metaplastic switch controlling bidirectional plasticity of feedforward inhibition

21 January 2018

1 reference

mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082.

21 January 2018

1 reference

Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies

21 January 2018

1 reference

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology

21 January 2018

1 reference

Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors.

21 January 2018

1 reference

Microglia and neuroprotection: from in vitro studies to therapeutic applications

21 January 2018

1 reference

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

21 January 2018

1 reference

The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice

21 January 2018

1 reference

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

21 January 2018

1 reference

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.

21 January 2018

1 reference

Neuroprotection against hypoxic/hypoglycaemic injury after the insult by the group III metabotropic glutamate receptor agonist (R, S)-4-phosphonophenylglycine

21 January 2018

1 reference

The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

21 January 2018

1 reference

The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases

21 January 2018

1 reference

Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain

21 January 2018

1 reference

Activation of NADPH oxidase in Alzheimer's disease brains.

21 January 2018

1 reference

Molecular dissection of reactive astrogliosis and glial scar formation

21 January 2018

1 reference

Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

21 January 2018

1 reference

The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

21 January 2018

1 reference

In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

21 January 2018

1 reference

Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms

21 January 2018

1 reference

Lack of motor symptoms progression in Parkinson's disease patients with long-term bilateral subthalamic deep brain stimulation

21 January 2018

1 reference

Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport

21 January 2018

1 reference

Proton magnetic resonance spectroscopy in Huntington's disease: evidence in favour of the glutamate excitotoxic theory

21 January 2018

1 reference

Protection of nigral cell death by bilateral subthalamic nucleus stimulation

21 January 2018

1 reference

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord

21 January 2018

1 reference

Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis

21 January 2018

1 reference

AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala

21 January 2018

1 reference

Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons

21 January 2018

1 reference

Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study

21 January 2018

1 reference

Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease.

21 January 2018

1 reference

Selective activation of group III metabotropic glutamate receptors by L-(+)-2-amino-4-phosphonobutryic acid protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.

21 January 2018

1 reference

Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model

21 January 2018

1 reference

Protective effects of NSAIDs on the development of Alzheimer disease

21 January 2018

1 reference

Molecular and cellular mechanisms of excitotoxic neuronal death

21 January 2018

1 reference

Activation of protein kinase C reduces GLAST in the plasma membrane of rat Müller cells in primary culture

21 January 2018

1 reference

Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

21 January 2018

1 reference

The effects of metabotropic glutamate receptor 7 allosteric agonist N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinas

21 January 2018

1 reference

Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage

21 January 2018

1 reference

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

21 January 2018

1 reference

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

21 January 2018

1 reference

Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

21 January 2018

1 reference

The role of microglia in paraquat-induced dopaminergic neurotoxicity

21 January 2018

1 reference

Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes.

21 January 2018

1 reference

Evidence that the loss of the voltage-dependent Mg2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism

21 January 2018

1 reference

Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake

21 January 2018

1 reference

Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.12608

1 reference

Consolidated OpenCitations Corpus – April 2017

release_ajrrubomkjhlrnssbiwumu43ti

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ajrrubomkjhlrnssbiwumu43ti

mapped directly with Wikidata item

24 November 2022

based on heuristic

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

24224472

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Consolidated OpenCitations Corpus – April 2017