New vitamin D analogs as potential therapeutics in melanoma (Q27001080)

Expert Review of Anticancer Therapy

published in

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volume

12

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issue

5

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page(s)

585-99

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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Melanin pigmentation in mammalian skin and its hormonal regulation

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Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

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Vitamin D and cancer: a review of molecular mechanisms

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High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

28 September 2017

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Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)₂vitamin D₃: genomic and non-genomic mechanisms

28 September 2017

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ERp57/GRP58: a protein with multiple functions.

28 September 2017

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1α,25(OH)₂-vitamin D and a nongenomic vitamin D analogue inhibit ultraviolet radiation-induced skin carcinogenesis.

28 September 2017

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Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP)

28 September 2017

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KIT as a therapeutic target in metastatic melanoma

28 September 2017

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28 September 2017

Melanoma and vitamin D

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Expression of vitamin D receptor decreases during progression of pigmented skin lesions.

28 September 2017

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Vitamin D: an ancient hormone

28 September 2017

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20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

28 September 2017

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Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate.

28 September 2017

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Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity.

28 September 2017

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Cutaneous vitamin D synthesis versus skin cancer development: The Janus faces of solar UV-radiation

28 September 2017

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Intestinal Cell Calcium Uptake and the Targeted Knockout of the 1,25D3-MARRS (Membrane-associated, Rapid Response Steroid-binding) Receptor/PDIA3/Erp57

28 September 2017

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Activation of vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling pathways through 1,25(OH)(2)D(3) in melanoma cell lines and other skin-derived cell lines

28 September 2017

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In defense of the sun: An estimate of changes in mortality rates in the United States if mean serum 25-hydroxyvitamin D levels were raised to 45 ng/mL by solar ultraviolet-B irradiance

28 September 2017

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28 September 2017

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Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

28 September 2017

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28 September 2017

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VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells

28 September 2017

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Vitamin D: newly discovered actions require reconsideration of physiologic requirements

28 September 2017

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Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial

28 September 2017

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The unfavorable effect of the A allele of the vitamin D receptor promoter polymorphism A-1012G has different mechanisms related to susceptibility and outcome of malignant melanoma

28 September 2017

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A new steroidal 5,7-diene derivative, 3beta-hydroxyandrosta-5,7-diene-17beta-carboxylic acid, shows potent anti-proliferative activity

28 September 2017

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Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline

28 September 2017

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Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down

28 September 2017

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The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature

28 September 2017

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Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK

28 September 2017

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Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data

28 September 2017

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Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity

28 September 2017

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Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

28 September 2017

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28 September 2017

Vitamin D and melanoma

1 reference

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Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses

28 September 2017

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Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies

28 September 2017

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Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives

28 September 2017

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Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3beta, 17alpha, 20-triol and their bioactivity in melanoma cells

28 September 2017

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Melanoma--Part 1: epidemiology, risk factors, and prevention

28 September 2017

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Vitamin D and skin cancer: a meta-analysis

28 September 2017

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Nonclassic actions of vitamin D

28 September 2017

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Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma

28 September 2017

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Vitamin D receptor polymorphisms and the risk of cutaneous melanoma: a systematic review and meta-analysis

28 September 2017

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Vitamin D analogs: therapeutic applications and mechanisms for selectivity

28 September 2017

1 reference

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20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

28 September 2017

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Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study.

28 September 2017

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Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

28 September 2017

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Vitamin D and the skin: an ancient friend, revisited

28 September 2017

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In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells

28 September 2017

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1alpha,25-Dihydroxyvitamin D3 modulates the response of human keratinocytes to ionizing radiation exposure

28 September 2017

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Antiproliferative activity of vitamin D compounds in combination with cytostatics

28 September 2017

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Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism

28 September 2017

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Vitamin D: its role in cancer prevention and treatment

28 September 2017

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Vitamin D signaling is modulated on multiple levels in health and disease.

28 September 2017

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Mechanisms for the selective action of Vitamin D analogs

28 September 2017

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Sun exposure and mortality from melanoma

28 September 2017

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A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3368500

A novel polymorphism in the 1A promoter region of the vitamin D receptor is associated with altered susceptibilty and prognosis in malignant melanoma.

28 September 2017

1 reference

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Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro

28 September 2017

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Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein

28 September 2017

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Profiling 1,25-dihydroxyvitamin D3-regulated gene expression by microarray analysis

28 September 2017

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Impaired nuclear localization of vitamin D receptor in leukemia cells resistant to calcitriol-induced differentiation

28 September 2017

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A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

28 September 2017

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Epidemiology of melanoma and nonmelanoma skin cancer

28 September 2017

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Vitamin D: A millenium perspective

28 September 2017

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Influence of vitamin D3 metabolites on cell proliferation and cytotoxicity of adriamycin in human normal and neoplastic cells

28 September 2017

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Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression

28 September 2017

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Neuroendocrinology of the skin

28 September 2017

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Resistance of HBL100 human breast epithelial cells to vitamin D action

28 September 2017

1 reference

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Differential apoptotic response of human melanoma cells to 1 alpha,25-dihydroxyvitamin D3 and its analogues.

28 September 2017

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Down-regulation of laminin-binding integrins by 1 alpha,25-dihydroxyvitamin D3 in human melanoma cells in vitro.

28 September 2017

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The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms

28 September 2017

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A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): structure-function implications

31 May 2018

1 reference

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Neuroendocrine activity of the melanocyte

31 May 2018

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Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

31 May 2018

1 reference

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Vitamin D protects keratinocytes from deleterious effects of ionizing radiation

31 May 2018

1 reference

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Polymorphisms in the MTHFR and VDR genes and skin cancer risk

31 May 2018

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An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

31 May 2018

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Stimulation of melanogenesis in cultured melanoma cells by calciferols

31 May 2018

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Vitamin D, its precursors, and metabolites do not affect melanization of cultured human melanocytes

31 May 2018

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Vitamin D production after UVB exposure depends on baseline vitamin D and total cholesterol but not on skin pigmentation

31 May 2018

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PLX4032 and melanoma: resistance, expectations and uncertainty.

21 January 2018

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Breast cancer cell regulation by high-dose Vitamin D compounds in the absence of nuclear vitamin D receptor

21 January 2018

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21 January 2018

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Antiapoptotic action of 1alpha,25-dihydroxyvitamin D3 in primary human melanocytes

21 January 2018

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Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake

21 January 2018

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Nuclear translocation of the 1,25D3-MARRS (membrane associated rapid response to steroids) receptor protein and NFkappaB in differentiating NB4 leukemia cells.

21 January 2018

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Association between cutaneous melanoma, Breslow thickness and vitamin D receptor BsmI polymorphism

21 January 2018

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Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid

21 January 2018

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Vitamin D receptor variants and the malignant melanoma risk: a population-based study

28 November 2018

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12 December 2020

Cutaneous malignant melanoma: ESMO clinical recommendations for diagnosis, treatment and follow-up

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12 December 2020

1,25-dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture

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12 December 2020

1alpha,25-dihydroxyvitamin D3 inhibits in vitro invasiveness through the extracellular matrix and in vivo pulmonary metastasis of B16 mouse melanoma

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12 December 2020

Cutaneous Malignant Melanoma

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12 December 2020

Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.

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12 December 2020

DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma

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12 December 2020

Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma

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12 December 2020

Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D3 metabolites

1 reference

12 December 2020

Vitamin D receptor and growth inhibition by 1,25-dihydroxyvitamin D3 in human malignant melanoma cell lines

1 reference

12 December 2020

Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma

1 reference

12 December 2020

Identifiers

0 references

1 reference

PubMed publication ID

22594894

1 reference