Interaction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanisms (Q27001177)

author name string

Christopher D. Morrone

series ordinal

1

1 reference

Mingzhe Liu

series ordinal

2

1 reference

JoAnne McLaurin

series ordinal

4

1 reference

language of work or name

1 reference

2015

1 reference

Frontiers in Aging Neuroscience

published in

1 reference

volume

7

1 reference

page(s)

64

1 reference

Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence

cites work

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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

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Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

21 March 2017

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Vascular risk factors and dementia: how to move forward?

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The neuregulin-I/ErbB signaling system in development and disease

21 March 2017

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 March 2017

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 March 2017

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RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 March 2017

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 March 2017

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Alzheimer's disease: genes, proteins, and therapy

21 March 2017

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Inflammation and Alzheimer's disease

21 March 2017

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 March 2017

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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

21 March 2017

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Virchow-Robin spaces at MR imaging

21 March 2017

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Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity

21 March 2017

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The pathogenesis of atherosclerosis: a perspective for the 1990s

21 March 2017

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Sleep drives metabolite clearance from the adult brain

7 April 2017

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

7 April 2017

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Molecular analysis of mammalian circadian rhythms

7 April 2017

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Blood-brain barrier breakdown in the aging human hippocampus

7 April 2017

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The association between cardiovascular risk factors and progressive hippocampus volume loss in persons with Alzheimer's disease

28 September 2017

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Sleep disturbances and dementia

28 September 2017

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Type 2 diabetes mellitus and Alzheimer's disease

28 September 2017

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Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

28 September 2017

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Cognitive health and Mediterranean diet: just diet or lifestyle pattern?

28 September 2017

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Can sleep apnea cause Alzheimer's disease?

28 September 2017

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New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy

28 September 2017

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Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

28 September 2017

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Physical activity attenuates age-related biomarker alterations in preclinical AD

28 September 2017

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Impairment of paravascular clearance pathways in the aging brain

28 September 2017

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Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

28 September 2017

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Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial.

28 September 2017

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Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study

28 September 2017

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Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability

28 September 2017

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The trouble with circadian clock dysfunction: multiple deleterious effects on the brain and body

28 September 2017

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Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies

28 September 2017

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Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain

28 September 2017

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Blood-brain-barriers in aging and in Alzheimer's disease

28 September 2017

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Self-reported sleep and β-amyloid deposition in community-dwelling older adults

28 September 2017

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Implication of the nutritional and nonnutritional factors in the context of preservation of cognitive performance in patients with dementia/depression and Alzheimer disease

28 September 2017

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Bridging animal and human models of exercise-induced brain plasticity

28 September 2017

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Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation?

28 September 2017

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Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

28 September 2017

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Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models

28 September 2017

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Proinflammatory cytokines, aging, and age-related diseases

28 September 2017

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Is there a cerebral lymphatic system?

28 September 2017

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Calcium channel blockers and dementia

28 September 2017

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Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

28 September 2017

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Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

28 September 2017

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The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities

28 September 2017

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Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease

28 September 2017

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Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year

28 September 2017

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A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease

28 September 2017

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Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease

28 September 2017

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28 September 2017

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28 September 2017

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Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where

28 September 2017

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

28 September 2017

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The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

28 September 2017

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Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

28 September 2017

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Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease

28 September 2017

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Roles of extracellular chaperones in amyloidosis

28 September 2017

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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

28 September 2017

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RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease

28 September 2017

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Solanezumab for Alzheimer's disease

28 September 2017

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Amyloid clearance as a treatment target against Alzheimer's disease.

28 September 2017

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PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease

28 September 2017

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Immunotherapy for Alzheimer's disease

28 September 2017

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Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

28 September 2017

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The role of microglia in amyloid clearance from the AD brain

28 September 2017

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Serum lipid levels and cognitive change in late life

28 September 2017

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Pathophysiology of the lymphatic drainage of the central nervous system: Implications for pathogenesis and therapy of multiple sclerosis

28 September 2017

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Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apnea

28 September 2017

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Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases

28 September 2017

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Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.

28 September 2017

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Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.

28 September 2017

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Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis

28 September 2017

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Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy.

28 September 2017

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Caloric restriction improves memory in elderly humans

28 September 2017

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Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.

28 September 2017

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Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

28 September 2017

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Cerebral amyloid angiopathy and its relationship to Alzheimer's disease.

28 September 2017

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Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease.

28 September 2017

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Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

28 September 2017

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Alzheimer's disease - the ways of prevention

28 September 2017

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Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

28 September 2017

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SIRT1 and neuronal diseases

28 September 2017

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28 September 2017

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Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

28 September 2017

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The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain

28 September 2017

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

28 September 2017

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28 September 2017

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Understanding RAGE, the receptor for advanced glycation end products

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Microscopic morphology and histology of the human meninges

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

An 18-year follow-up of overweight and risk of Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Sporadic and familial cerebral amyloid angiopathies.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

A liposome-based therapeutic vaccine against beta -amyloid plaques on the pancreas of transgenic NORBA mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Sleep disordered breathing in the elderly.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Antiplatelet therapy using cilostazol, a specific PDE3 inhibitor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Efflux of radiolabeled polyethylene glycols and albumin from rat brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Drainage of interstitial fluid from different regions of rat brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Differential degeneration of the cerebral microvasculature in Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Venular degeneration leads to vascular dysfunction in a transgenic model of Alzheimer's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Relationships between performance on the Cogstate Brief Battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Prenatal high-fat diet alters the cerebrovasculature and clearance of β-amyloid in adult offspring

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Failure of perivascular drainage of β-amyloid in cerebral amyloid angiopathy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Treadmill training as an augmentation treatment for Alzheimer's disease: a pilot randomized controlled study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

CSF beta-amyloid levels are altered in narcolepsy: a link with the inflammatory hypothesis?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Correlation between inflammatory markers of atherosclerosis and carotid intima-media thickness in Obstructive Sleep Apnea.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Benefits of multimodal exercise intervention for postural control and frontal cognitive functions in individuals with Alzheimer's disease: a controlled trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Effect of cilostazol in acute lacunar infarction based on pulsatility index of transcranial Doppler (ECLIPse): a multicenter, randomized, double-blind, placebo-controlled trial.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer's disease: a pilot randomized controlled trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Safety and biomarker effects of solanezumab in patients with Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: a pilot study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

In vivo uptake of β-amyloid by non-plaque associated microglia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Six-month walking program changes cognitive and ADL performance in patients with Alzheimer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Microbleed Topography, Leukoaraiosis, and Cognition in Probable Alzheimer Disease From the Sunnybrook Dementia Study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Nilvadipine prevents cognitive decline of patients with mild cognitive impairment

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Mechanisms to explain the reverse perivascular transport of solutes out of the brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Increased risk of type 2 diabetes in Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Caloric intake and the risk of Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Metabolic regulation of brain Abeta by neprilysin

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419721

Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals

28 November 2018

1 reference

12 December 2020

Dietary patterns and cognitive dysfunction in a 12-year follow-up study of 70 year old men

1 reference

12 December 2020

A controlled clinical trial on the effects of exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer's disease

1 reference

12 December 2020

Periventricular venous collagenosis: association with leukoaraiosis

1 reference

12 December 2020

Fluid mechanics in the perivascular space

1 reference

12 December 2020

Astrocytes: a cellular player in Abeta clearance and degradation

1 reference

12 December 2020

Identifiers

DOI

10.3389/FNAGI.2015.00064

0 references

1 reference

PubMed publication ID

25999850

1 reference