ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling (Q27001701)

Crossref

Chuanyue Wu

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

October 2012

1 reference

Current Opinion in Cell Biology

published in

1 reference

volume

24

1 reference

issue

5

1 reference

page(s)

607-13

1 reference

PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

21 March 2017

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EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility

21 March 2017

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Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase

21 March 2017

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The structural basis of integrin-linked kinase-PINCH interactions

21 March 2017

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Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

21 March 2017

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Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility

21 March 2017

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The protein kinase complement of the human genome

21 March 2017

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Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

21 March 2017

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A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction

21 March 2017

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A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

21 March 2017

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Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily

21 March 2017

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The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

21 March 2017

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Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

21 March 2017

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The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

21 March 2017

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Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

21 March 2017

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The Structure of -Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly

21 March 2017

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PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

21 March 2017

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Integrin signalling adaptors: not only figurants in the cancer story

21 March 2017

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Integrin-linked kinase is an adaptor with essential functions during mouse development

21 March 2017

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Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase

21 March 2017

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Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation

21 March 2017

1 reference

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Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

21 March 2017

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Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality

21 March 2017

1 reference

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PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

21 March 2017

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PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes

21 March 2017

1 reference

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Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

21 March 2017

1 reference

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LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.

21 March 2017

1 reference

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Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy

28 September 2017

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Integrin-linked kinase: not so 'pseudo' after all.

28 September 2017

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How integrins control mammary epithelial differentiation: a possible role for the ILK-PINCH-Parvin complex

28 September 2017

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Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase.

28 September 2017

1 reference

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A central multifunctional role of integrin-linked kinase at muscle attachment sites.

28 September 2017

1 reference

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Pseudokinases-remnants of evolution or key allosteric regulators?

28 September 2017

1 reference

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A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

28 September 2017

1 reference

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PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha

28 September 2017

1 reference

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The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

28 September 2017

1 reference

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Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.

28 September 2017

1 reference

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Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails

28 September 2017

1 reference

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Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

Integrin-linked kinase--essential roles in physiology and cancer biology.

28 September 2017

1 reference

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Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

Emerging roles of pseudokinases

28 September 2017

1 reference

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PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions

28 September 2017

1 reference

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The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.

28 September 2017

1 reference

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Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

The PINCH-ILK-parvin complexes: assembly, functions and regulation.

28 September 2017

1 reference

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Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt

28 September 2017

1 reference

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Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation

31 May 2018

1 reference

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Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo

31 May 2018

1 reference

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Functional analysis of parvin and different modes of IPP-complex assembly at integrin sites during Drosophila development.

31 May 2018

1 reference

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Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.

28 November 2018

1 reference

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Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscle

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

28 November 2018

1 reference

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Analysis of PINCH function inDrosophilademonstrates its requirement in integrin-dependent cellular processes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332

10.1016/J.CEB.2012.06.003

28 November 2018

Identifiers

DOI

0 references

1 reference

PubMed publication ID

22763012

1 reference