LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration. (Q35987858)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441983%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration (English)

1 reference

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26 January 2020

0 references

1 reference

1 reference

8

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26 January 2020

author name string

Julie Devallière

1

1 reference

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26 January 2020

Mathias Chatelais

2

1 reference

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26 January 2020

Juliette Fitau

3

1 reference

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26 January 2020

Nathalie Gérard

4

1 reference

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26 January 2020

Philippe Hulin

5

1 reference

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26 January 2020

Laura Velazquez

6

1 reference

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26 January 2020

Christopher E Turner

7

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26 January 2020

language of work or name

English

0 references

publication date

21 March 2012

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26 January 2020

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26 January 2020

volume

26

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26 January 2020

issue

6

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26 January 2020

page(s)

2592-2606

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describes a project that uses

26 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3360145/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling

2 October 2017

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PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling.

2 October 2017

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Integrin-linked kinase: not so 'pseudo' after all.

2 October 2017

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Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion

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Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation

2 October 2017

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PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha

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Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo

2 October 2017

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The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

2 October 2017

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The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

2 October 2017

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alphavbeta5/beta6 integrin suppression leads to a stimulation of alpha2beta1 dependent cell migration resistant to PI3K/Akt inhibition

2 October 2017

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One-dimensional topography underlies three-dimensional fibrillar cell migration

2 October 2017

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Integrin-linked kinase--essential roles in physiology and cancer biology.

2 October 2017

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Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

2 October 2017

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Integrins in angiogenesis and lymphangiogenesis

2 October 2017

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Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

2 October 2017

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Functional atlas of the integrin adhesome

2 October 2017

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Vascular remodeling in transplant vasculopathy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

2 October 2017

1 reference

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Emerging roles of pseudokinases

2 October 2017

1 reference

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The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways

2 October 2017

1 reference

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ILK, PINCH and parvin: the tIPP of integrin signalling

2 October 2017

1 reference

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The interaction between the adaptor protein APS and Enigma is involved in actin organisation

2 October 2017

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Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways

2 October 2017

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Focal adhesion kinase: in command and control of cell motility

2 October 2017

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Integrin-linked kinase: a cancer therapeutic target unique among its ILK.

2 October 2017

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Paxillin: adapting to change

2 October 2017

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Phosphorylation of actopaxin regulates cell spreading and migration

2 October 2017

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Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis

2 October 2017

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Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains

2 October 2017

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PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

2 October 2017

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Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2

2 October 2017

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Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice

2 October 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2 October 2017

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Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein

2 October 2017

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Paxillin and focal adhesion signalling

2 October 2017

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Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion

2 October 2017

1 reference

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Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins

2 October 2017

1 reference

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Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Cell migration as a five-step cycle.

2 October 2017

1 reference

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2 October 2017

1 reference

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Characterization of Lnk. An adaptor protein expressed in lymphocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Cell migration: a physically integrated molecular process

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Gene transfer of the adaptor Lnk (SH2B3) prevents porcine endothelial cell activation and apoptosis: implication for xenograft's cytoprotection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Pivotal role of lnk adaptor protein in endothelial progenitor cell biology for vascular regeneration.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Regulation of cell-matrix adhesion dynamics and Rac-1 by integrin linked kinase.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

An automated method to quantify and visualize colocalized fluorescent signals.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360145

Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly

24 September 2018

1 reference

12 December 2020

Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation

1 reference

12 December 2020

Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells

1 reference

12 December 2020

Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein

1 reference

12 December 2020

Identifiers

DOI

10.1096/FJ.11-193383

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441983%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441983%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22441983%20AND%20SRC:MED&resulttype=core&format=json