Top-down proteomics in health and disease: challenges and opportunities (Q27002139)

Ying Ge

series ordinal

2

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language of work or name

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May 2014

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14

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issue

10

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page(s)

1195-210

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S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10

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Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry

21 March 2017

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Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail.

21 March 2017

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Large-scale analysis of the yeast proteome by multidimensional protein identification technology

21 March 2017

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Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytes

21 March 2017

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Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

21 March 2017

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21 March 2017

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Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease

21 March 2017

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Mapping intact protein isoforms in discovery mode using top-down proteomics

21 March 2017

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Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure

21 March 2017

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Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

21 March 2017

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Top-down mass spectrometry of integral membrane proteins

21 March 2017

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Extending top-down mass spectrometry to proteins with masses greater than 200 kilodaltons

21 March 2017

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Chemistry. Mass spectrometry: bottom-up or top-down?

21 March 2017

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Mass spectrometry-based proteomics turns quantitative

21 March 2017

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Regulation of cardiac contractile function by troponin I phosphorylation

21 March 2017

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Heart disease and stroke statistics--2012 update: a report from the American Heart Association

7 April 2017

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MAP kinase signalling pathways in cancer

7 April 2017

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Proteomic analysis of post-translational modifications

7 April 2017

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7 April 2017

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Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage

28 September 2017

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The emergence of top-down proteomics in clinical research

28 September 2017

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Top-down proteomics reveals a unique protein S-thiolation switch in Salmonella Typhimurium in response to infection-like conditions.

28 September 2017

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Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation

28 September 2017

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Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ

28 September 2017

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Significant modifications of the salivary proteome potentially associated with complications of Down syndrome revealed by top-down proteomics

28 September 2017

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Mass spectrometry of intact membrane protein complexes

28 September 2017

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Proteoform: a single term describing protein complexity

28 September 2017

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Top down proteomics of human membrane proteins from enriched mitochondrial fractions

28 September 2017

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Top-down targeted proteomics for deep sequencing of tropomyosin isoforms

28 September 2017

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Next-generation proteomics: towards an integrative view of proteome dynamics.

28 September 2017

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Enhanced top-down characterization of histone post-translational modifications

28 September 2017

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Comprehensive analysis of protein modifications by top-down mass spectrometry

28 September 2017

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Mass spectrometry-based proteomics for systems biology

28 September 2017

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Intact proteome fractionation strategies compatible with mass spectrometry.

28 September 2017

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The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives

28 September 2017

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Augmented phosphorylation of cardiac troponin I in hypertensive heart failure

28 September 2017

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Protein identification using top-down.

28 September 2017

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Unit mass baseline resolution for an intact 148 kDa therapeutic monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry

28 September 2017

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A mechanical nanomembrane detector for time-of-flight mass spectrometry

28 September 2017

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On the scalability and requirements of whole protein mass spectrometry

28 September 2017

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Analysis of intact protein isoforms by mass spectrometry.

28 September 2017

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Top-Down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap. Potential for Mass Spectrometry-Based Clinical Assays for Transthyretin and Hemoglobin

28 September 2017

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Protein signatures for survival and recurrence in metastatic melanoma

28 September 2017

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Building multidimensional biomarker views of type 2 diabetes on the basis of protein microheterogeneity

28 September 2017

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Posttranslational modification of pili upon cell contact triggers N. meningitidis dissemination

28 September 2017

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28 September 2017

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Inside the human cancer tyrosine phosphatome

28 September 2017

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28 September 2017

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Achievements and perspectives of top-down proteomics.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality

28 September 2017

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Quantitative analysis of intact apolipoproteins in human HDL by top-down differential mass spectrometry

28 September 2017

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Deciphering modifications in swine cardiac troponin I by top-down high-resolution tandem mass spectrometry

28 September 2017

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Investigation of an albumin-enriched fraction of human serum and its albuminome

28 September 2017

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Quantitative top-down proteomics of SILAC labeled human embryonic stem cells.

28 September 2017

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Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry

28 September 2017

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High resolution electron transfer dissociation studies of unfractionated intact histones from murine embryonic stem cells using on-line capillary LC separation: determination of abundant histone isoforms and post-translational modifications

28 September 2017

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Analysis of human C1q by combined bottom-up and top-down mass spectrometry: detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites

28 September 2017

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In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.

28 September 2017

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A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop

28 September 2017

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Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data

28 September 2017

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Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry

28 September 2017

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A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection

28 September 2017

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Top-down identification and quantification of stable isotope labeled proteins from Aspergillus flavus using online nano-flow reversed-phase liquid chromatography coupled to a LTQ-FTICR mass spectrometer

28 September 2017

1 reference

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Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.

28 September 2017

1 reference

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The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

28 September 2017

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Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?

28 September 2017

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Decoding protein modifications using top-down mass spectrometry

28 September 2017

1 reference

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ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry

28 September 2017

1 reference

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Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases

28 September 2017

1 reference

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Definition of the mitochondrial proteome by measurement of molecular masses of membrane proteins

28 September 2017

1 reference

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Posttranslational protein modifications: current implications for cancer detection, prevention, and therapeutics

28 September 2017

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Population proteomics: the concept, attributes, and potential for cancer biomarker research

28 September 2017

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Using size exclusion chromatography-RPLC and RPLC-CIEF as two-dimensional separation strategies for protein profiling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Troponin: the biomarker of choice for the detection of cardiac injury

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Incidence and epidemiology of heart failure

28 September 2017

1 reference

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Genetic causes of human heart failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Role of chromatographic techniques in proteomic analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

The role of electron capture dissociation in biomolecular analysis.

28 September 2017

1 reference

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Molecular and integrated biology of thin filament protein phosphorylation in heart muscle

28 September 2017

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Mass spectrometric immunoassay

28 September 2017

1 reference

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Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Mass spectrometric analysis of DNA mixtures: instrumental effects responsible for decreased sensitivity with increasing mass

28 September 2017

1 reference

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Proteomics: the first decade and beyond

28 September 2017

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Mechanism of charging and supercharging molecules in electrospray ionization

28 September 2017

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Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins

28 September 2017

1 reference

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Full subunit coverage liquid chromatography electrospray ionization mass spectrometry (LCMS+) of an oligomeric membrane protein: cytochrome b(6)f complex from spinach and the cyanobacterium Mastigocladus laminosus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Histone deacetylases and cancer: causes and therapies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Affinity chromatography: a review of clinical applications.

28 September 2017

1 reference

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Tandem chromatographic-immunological analyses

28 September 2017

1 reference

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Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Ultrahigh pressure fast size exclusion chromatography for top-down proteomics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Identification of post-translational modifications by blind search of mass spectra.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100610

Proteomics: biology in the post-genomic era. Companies all over the world rush to lead the way in the new post-genomics race

31 May 2018

1 reference

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Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

31 May 2018

1 reference

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Cerebrospinal fluid top-down proteomics evidenced the potential biomarker role of LVV- and VV-hemorphin-7 in posterior cranial fossa pediatric brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Detection of genetic variants of transthyretin by liquid chromatography-dual electrospray ionization fourier-transform ion-cyclotron-resonance mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

NCα Bond Dissociation Energies and Kinetics in Amide and Peptide Radicals. Is the Dissociation a Non-ergodic Process?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Top-down quantitation and characterization of SILAC-labeled proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Application of metal-coded affinity tags (MeCAT): absolute protein quantification with top-down and bottom-up workflows by metal-coded tagging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Automated reduction and interpretation of high resolution electrospray mass spectra of large molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Precursor ion independent algorithm for top-down shotgun proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

Proteomic Profiling of Intact Proteins Using WAX-RPLC 2-D Separations and FTICR Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201300432

HPLC and mass spectrometry of intrinsic membrane proteins

21 January 2018

1 reference

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Electron transfer dissociation mass spectrometry of hemoglobin on clinical samples

28 November 2018

1 reference

12 December 2020

Mass spectrometry as an emerging tool for systems biology

1 reference

12 December 2020

In-Spray Supercharging of Peptides and Proteins in Electrospray Ionization Mass Spectrometry

1 reference

12 December 2020

Dynamically harmonized FT-ICR cell with specially shaped electrodes for compensation of inhomogeneity of the magnetic field. Computer simulations of the electric field and ion motion dynamics

1 reference

12 December 2020

Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure

1 reference

12 December 2020

Tearing the top off 'Top-Down' Proteomics

1 reference

12 December 2020

Electron capture dissociation for structural characterization of multiply charged protein cations

1 reference

12 December 2020

Detailed Unfolding and Folding of Gaseous Ubiquitin Ions Characterized by Electron Capture Dissociation

1 reference

12 December 2020

Top-Down Proteomics and Direct Surface Sampling of Neonatal Dried Blood Spots: Diagnosis of Unknown Hemoglobin Variants

1 reference

12 December 2020

Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.1002/PMIC.201300432

0 references

1 reference

PubMed publication ID

24723472

1 reference