Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure (Q28243166)

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7 February 2020

title

Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure (English)

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7 February 2020

0 references

0 references

1 reference

chronic heart failure

1 reference

7

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7 February 2020

author name string

Jiang Zhang

1

1 reference

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7 February 2020

Moltu J Guy

2

1 reference

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7 February 2020

Holly S Norman

3

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7 February 2020

Yi-Chen Chen

4

1 reference

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7 February 2020

Qingge Xu

5

1 reference

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7 February 2020

Xintong Dong

6

1 reference

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7 February 2020

Sijian Wang

8

1 reference

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7 February 2020

Takushi Kohmoto

9

1 reference

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7 February 2020

Ken H Young

10

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7 February 2020

Richard L Moss

11

1 reference

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7 February 2020

Ying Ge

12

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7 February 2020

language of work or name

English

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publication date

28 July 2011

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Journal of Proteome Research

7 February 2020

published in

1 reference

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7 February 2020

volume

10

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7 February 2020

issue

9

1 reference

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7 February 2020

page(s)

4054-4065

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Why does troponin I have so many phosphorylation sites? Fact and fancy

7 February 2020

cites work

1 reference

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Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

20 March 2017

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Use of multiple biomarkers to improve the prediction of death from cardiovascular causes

20 March 2017

1 reference

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Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure

20 March 2017

1 reference

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Extending top-down mass spectrometry to proteins with masses greater than 200 kilodaltons

20 March 2017

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Chemistry. Mass spectrometry: bottom-up or top-down?

20 March 2017

1 reference

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Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

20 March 2017

1 reference

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Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

20 March 2017

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The human plasma proteome: history, character, and diagnostic prospects

20 March 2017

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Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue

20 March 2017

1 reference

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Cardiac troponin I is modified in the myocardium of bypass patients

20 March 2017

1 reference

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Transgenic mouse model of stunned myocardium

20 March 2017

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Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury

20 March 2017

1 reference

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Regulation of cardiac contractile function by troponin I phosphorylation

20 March 2017

1 reference

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Proteomic analysis of post-translational modifications

6 April 2017

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On the development of plasma protein biomarkers

7 April 2017

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Multiplex assays for biomarker research and clinical application: translational science coming of age.

29 September 2017

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Novel biomarkers in cardiovascular disease: update 2010.

29 September 2017

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Achievements and perspectives of top-down proteomics.

29 September 2017

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The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput

29 September 2017

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Galectin-3 is a candidate biomarker for amyotrophic lateral sclerosis: discovery by a proteomics approach

29 September 2017

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Early detection of myocardial dysfunction and heart failure

29 September 2017

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Early identification of cardiovascular risk using genomics and proteomics

29 September 2017

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Quantitative analysis of intact apolipoproteins in human HDL by top-down differential mass spectrometry

29 September 2017

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Deciphering modifications in swine cardiac troponin I by top-down high-resolution tandem mass spectrometry

29 September 2017

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Quantitative top-down proteomics of SILAC labeled human embryonic stem cells.

29 September 2017

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Post-translational modifications of integral membrane proteins resolved by top-down Fourier transform mass spectrometry with collisionally activated dissociation

29 September 2017

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Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background

29 September 2017

1 reference

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Glycomics and disease markers

29 September 2017

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In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.

29 September 2017

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Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 automethylation using top-down high resolution tandem mass spectrometry

29 September 2017

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Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins

29 September 2017

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Mining the plasma proteome for cancer biomarkers

29 September 2017

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Tackling heart failure in the twenty-first century

29 September 2017

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The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

29 September 2017

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Sarcomeric dysfunction in heart failure.

29 September 2017

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Decoding protein modifications using top-down mass spectrometry

29 September 2017

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Cardiac GPCRs: GPCR signaling in healthy and failing hearts

29 September 2017

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Cardiovascular proteomics: tools to develop novel biomarkers and potential applications

29 September 2017

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Capillary separations enabling tissue proteomics-based biomarker discovery

29 September 2017

1 reference

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Protein biomarker discovery and validation: the long and uncertain path to clinical utility

29 September 2017

1 reference

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Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications

29 September 2017

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Posttranslational protein modifications: current implications for cancer detection, prevention, and therapeutics

29 September 2017

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Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights

29 September 2017

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Biomarkers of cardiovascular disease: molecular basis and practical considerations

29 September 2017

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Stepwise deamidation of ribonuclease A at five sites determined by top down mass spectrometry

29 September 2017

1 reference

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Troponin: the biomarker of choice for the detection of cardiac injury

29 September 2017

1 reference

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Developing the next generation of cardiac markers: disease-induced modifications of troponin I.

29 September 2017

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Antibody-based proteomics for human tissue profiling

29 September 2017

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The role of electron capture dissociation in biomolecular analysis.

29 September 2017

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The global burden of chronic diseases: overcoming impediments to prevention and control

29 September 2017

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Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications

29 September 2017

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What is the role of beta-adrenergic signaling in heart failure?

29 September 2017

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Strategy for analysis of cardiac troponins in biological samples with a combination of affinity chromatography and mass spectrometry

29 September 2017

1 reference

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Affinity chromatography: a review of clinical applications.

29 September 2017

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Calcium-activated neutral protease (calpain) system: structure, function, and regulation

29 September 2017

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Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry

29 September 2017

1 reference

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Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development

2 June 2018

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Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling

2 June 2018

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Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4.

27 November 2018

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Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins

27 November 2018

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Perspective: A Program to Improve Protein Biomarker Discovery for Cancer†

27 November 2018

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Stunned peri-infarct canine myocardium is characterized by degradation of troponin T, not troponin I.

27 November 2018

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Myocyte adrenoceptor signaling pathways

27 November 2018

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Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry

27 November 2018

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Degradation of cardiac troponin I: implication for reliable immunodetection.

27 November 2018

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Troponin I Proteolysis and Myocardial Stunning: Now You See It-Now You Don>>t

27 November 2018

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12 December 2020

Troponin I phosphorylation in the normal and failing adult human heart

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12 December 2020

Breakdown and release of myofilament proteins during ischemia and ischemia/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation

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12 December 2020

Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure

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12 December 2020

Tissue proteomics and metabolomics: an excellent start and a promising future

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12 December 2020

Electron capture dissociation for structural characterization of multiply charged protein cations

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12 December 2020

Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction

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12 December 2020

Phosphopeptide/phosphoprotein mapping by electron capture dissociation mass spectrometry

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12 December 2020

Identifiers

DOI

10.1021/PR200258M

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21751783%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21751783%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21751783

2 references