Targeted therapies in CLL: mechanisms of resistance and strategies for management (Q27002528)

Crossref

A. J. Johnson

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

23 July 2015

1 reference

1 reference

126

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PubMed

issue

4

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PubMed

page(s)

471-7

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Clonal evolution in hematological malignancies and therapeutic implications

PubMed

cites work

1 reference

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Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals

21 March 2017

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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

21 March 2017

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Mechanism of action of lenalidomide in hematological malignancies

21 March 2017

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

21 March 2017

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

21 March 2017

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Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

21 March 2017

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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

21 March 2017

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Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

21 March 2017

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Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

21 March 2017

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EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

21 March 2017

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Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

21 March 2017

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Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma

21 March 2017

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The BCL-2 protein family: opposing activities that mediate cell death

21 March 2017

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Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

7 April 2017

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

7 April 2017

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Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

7 April 2017

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Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia

28 September 2017

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MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

28 September 2017

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Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial

28 September 2017

1 reference

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Managing high-risk CLL during transition to a new treatment era: stem cell transplantation or novel agents?

28 September 2017

1 reference

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IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

28 September 2017

1 reference

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Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

28 September 2017

1 reference

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Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.

28 September 2017

1 reference

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Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study

28 September 2017

1 reference

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Obinutuzumab (GA101) in relapsed/refractory chronic lymphocytic leukemia: final data from the phase 1/2 GAUGUIN study

28 September 2017

1 reference

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Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma

28 September 2017

1 reference

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Targeting BCL2 for the treatment of lymphoid malignancies

28 September 2017

1 reference

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PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.

28 September 2017

1 reference

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Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia

28 September 2017

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Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma.

28 September 2017

1 reference

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Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL

28 September 2017

1 reference

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Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

28 September 2017

1 reference

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Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy

28 September 2017

1 reference

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Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer

28 September 2017

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Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

28 September 2017

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P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse

28 September 2017

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A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency

28 September 2017

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The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

28 September 2017

1 reference

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A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

28 September 2017

1 reference

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Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia

28 September 2017

1 reference

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Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group

28 September 2017

1 reference

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

28 September 2017

1 reference

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Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial

28 September 2017

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Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

28 September 2017

1 reference

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Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia

28 September 2017

1 reference

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Mechanisms of primary and secondary resistance to imatinib in chronic myeloid leukemia

28 September 2017

1 reference

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Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial

28 September 2017

1 reference

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Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

28 September 2017

1 reference

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Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

28 September 2017

1 reference

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Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study

28 September 2017

1 reference

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Ibrutinib antagonizes rituximab-dependent NK cell-mediated cytotoxicity

28 September 2017

1 reference

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Ibrutinib-naïve chronic lymphocytic leukemia lacks Bruton tyrosine kinase mutations associated with treatment resistance.

31 May 2018

1 reference

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The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia.

28 November 2018

1 reference

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4513250

Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation

28 November 2018

1 reference

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10.1182/BLOOD-2015-03-585075

28 November 2018

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

26065659

1 reference