Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases (Q27003070)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Eiji Yoshihara

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

So Masaki

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Zhe Chen

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Hai Tian

5

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Junji Yodoi

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

1 reference

9 January 2014

1 reference

published in

Frontiers in Immunology

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

4

2 references

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31 May 2020

page(s)

514

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation

31 May 2020

cites work

1 reference

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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

21 March 2017

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Positional cloning of the combined hyperlipidemia gene Hyplip1

21 March 2017

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ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction

21 March 2017

1 reference

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Crystal structure of the human thioredoxin reductase-thioredoxin complex

21 March 2017

1 reference

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The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin

21 March 2017

1 reference

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A role for mitochondria in NLRP3 inflammasome activation

21 March 2017

1 reference

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Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression

21 March 2017

1 reference

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Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1

21 March 2017

1 reference

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Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3

21 March 2017

1 reference

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A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy

21 March 2017

1 reference

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P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke

21 March 2017

1 reference

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On the origins of arrestin and rhodopsin

21 March 2017

1 reference

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Rapid induction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis

21 March 2017

1 reference

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Cloning and expression of a novel mammalian thioredoxin

21 March 2017

1 reference

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 March 2017

1 reference

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

7 April 2017

1 reference

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Protein tyrosine phosphatases: from genes, to function, to disease

7 April 2017

1 reference

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7 April 2017

1 reference

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Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

7 April 2017

1 reference

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AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

28 September 2017

1 reference

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Extracellular thioredoxin: a therapeutic tool to combat inflammation.

28 September 2017

1 reference

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Suppressive effect of administration of recombinant human thioredoxin on cutaneous inflammation caused by UV.

28 September 2017

1 reference

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Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach.

28 September 2017

1 reference

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Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence.

28 September 2017

1 reference

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Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

28 September 2017

1 reference

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IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

28 September 2017

1 reference

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Deficiency of thioredoxin binding protein-2 (TBP-2) enhances TGF-β signaling and promotes epithelial to mesenchymal transition

28 September 2017

1 reference

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TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy

28 September 2017

1 reference

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Preventing β-cell loss and diabetes with calcium channel blockers

28 September 2017

1 reference

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Diabetes mellitus and the β cell: the last ten years

28 September 2017

1 reference

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Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling

28 September 2017

1 reference

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Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus

28 September 2017

1 reference

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TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.

28 September 2017

1 reference

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Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue

28 September 2017

1 reference

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Oxidative stress, insulin signaling, and diabetes.

28 September 2017

1 reference

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Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2.

28 September 2017

1 reference

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Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Structure, function, and mechanism of thioredoxin proteins

28 September 2017

1 reference

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Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death

28 September 2017

1 reference

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Reactive oxygen species enhance insulin sensitivity

28 September 2017

1 reference

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Thioredoxin regulates cell cycle via the ERK1/2-cyclin D1 pathway

28 September 2017

1 reference

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Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.

28 September 2017

1 reference

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High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

28 September 2017

1 reference

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Thioredoxin binding protein-2/thioredoxin-interacting protein is a critical regulator of insulin secretion and peroxisome proliferator-activated receptor function

28 September 2017

1 reference

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Thioredoxin overexpression modulates remodeling factors in stress responses to cigarette smoke.

28 September 2017

1 reference

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Txnip balances metabolic and growth signaling via PTEN disulfide reduction

28 September 2017

1 reference

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Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1.

28 September 2017

1 reference

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TXNIP regulates peripheral glucose metabolism in humans

28 September 2017

1 reference

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Thioredoxin and related molecules--from biology to health and disease

28 September 2017

1 reference

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Cell signaling. H2O2, a necessary evil for cell signaling

28 September 2017

1 reference

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The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells

28 September 2017

1 reference

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Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.

28 September 2017

1 reference

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The thioredoxin system in retroviral infection and apoptosis

28 September 2017

1 reference

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Redox regulation of lung inflammation by thioredoxin

28 September 2017

1 reference

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Loss of thioredoxin-binding protein-2/vitamin D3 up-regulated protein 1 in human T-cell leukemia virus type I-dependent T-cell transformation: implications for adult T-cell leukemia leukemogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Letter: Two cases of T-cell chronic lymphocytic leukemia in Japan

28 September 2017

1 reference

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Molecular characterization of differentially expressed TXNIP gene and its association with porcine carcass traits.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Tumor suppressor VDUP1 increases p27(kip1) stability by inhibiting JAB1.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Characterization of Escherichia coli thioredoxin variants mimicking the active-sites of other thiol/disulfide oxidoreductases

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-interacting protein suppresses bladder carcinogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin binding protein-2 mediates metabolic adaptation in response to lipopolysaccharide in vivo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Characterization of the HDAC1 complex that regulates the sensitivity of cancer cells to oxidative stress.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic osteopenia: a novel role of oxidative stress and therapeutic implications.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Lack of TXNIP protects beta-cells against glucotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-1 promotes survival in cells exposed to S-nitrosoglutathione: Correlation with reduction of intracellular levels of nitrosothiols and up-regulation of the ERK1/2 MAP Kinases

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Hepatocellular carcinoma in Txnip-deficient mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Downregulation of metastasis suppressor genes in malignant pheochromocytoma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

General Acid/Base Catalysis in the Active Site ofEscherichia coliThioredoxin†

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3885921

Vitamin D3 upregulated protein 1 suppresses TNF-α-induced NF-κB activation in hepatocarcinogenesis

28 November 2018

1 reference

12 December 2020

Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis

1 reference

12 December 2020

Localization of thioredoxin-interacting protein (TXNIP) mRNA in epithelium of human gastrointestinal tract

1 reference

12 December 2020

Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice

1 reference

12 December 2020

TXNIP Links Redox Circuitry to Glucose Control

1 reference

12 December 2020

Effects of thioredoxin on established airway remodeling in a chronic antigen exposure asthma model

1 reference

12 December 2020

Mimicking the active site of protein disulfide-isomerase by substitution of proline 34 in Escherichia coli thioredoxin

1 reference

12 December 2020

Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses

1 reference

12 December 2020

Thioredoxin-1 suppresses systemic inflammatory responses against cigarette smoking

1 reference

12 December 2020

Excitotoxic hippocampal injury is attenuated in thioredoxin transgenic mice

1 reference

12 December 2020

TXNIP switches tracks toward a terminal UPR

1 reference

12 December 2020

Are the properties of mitochondrial membranes redox regulated?

1 reference

12 December 2020

VDUP1: a potential mediator of expansion-induced lung growth and epithelial cell differentiation in the ovine fetus

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2013.00514

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24409188%20AND%20SRC:MED&resulttype=core&format=json