Na+ channel function, regulation, structure, trafficking and sequestration (Q27005721)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25772290%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

review article

1 reference

title

Na+ channel function, regulation, structure, trafficking and sequestration (English)

1 reference

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2 March 2020

6

1 reference

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2 March 2020

Robin Shaw

2

1 reference

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2 March 2020

Vladimir Yarov-Yarovoy

4

1 reference

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2 March 2020

Eleonora Grandi

14

1 reference

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2 March 2020

Victor V Maltsev

18

1 reference

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2 March 2020

Donald M. Bers

25

1 reference

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2 March 2020

7

Richard W Aldrich

1 reference

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2 March 2020

23

Eric A Sobie

1 reference

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2 March 2020

author name string

Ye Chen-Izu

1

2 references

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2 March 2020

Luiz Belardinelli

8

2 references

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2 March 2020

Nipavan Chiamvimonvat

12

2 references

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2 March 2020

Isabelle Deschenes

13

2 references

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2 March 2020

Celine Marionneau

19

2 references

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2 March 2020

Sridharan Rajamani

21

2 references

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2 March 2020

Geoffrey S Pitt

3

1 reference

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2 March 2020

Jon T Sack

5

1 reference

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2 March 2020

Mark B Cannell

9

1 reference

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2 March 2020

William A Catterall

10

1 reference

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2 March 2020

Walter J Chazin

11

1 reference

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2 March 2020

Thomas J Hund

15

1 reference

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2 March 2020

Leighton T Izu

16

1 reference

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2 March 2020

Lars S Maier

17

1 reference

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2 March 2020

Peter J Mohler

20

1 reference

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2 March 2020

Randall L Rasmusson

22

1 reference

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2 March 2020

Colleen E Clancy

24

1 reference

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2 March 2020

language of work or name

1 reference

1 March 2015

1 reference

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2 March 2020

published in

Journal of Physiology

2 references

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2 March 2020

volume

593

2 references

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2 March 2020

issue

6

2 references

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2 March 2020

page(s)

1347-1360

1 reference

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The role of late I Na in development of cardiac arrhythmias

2 March 2020

cites work

1 reference

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The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years

21 March 2017

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Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

21 March 2017

1 reference

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Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

21 March 2017

1 reference

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SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes

21 March 2017

1 reference

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Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)

21 March 2017

1 reference

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Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

21 March 2017

1 reference

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Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway

21 March 2017

1 reference

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Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes

21 March 2017

1 reference

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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

21 March 2017

1 reference

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A calcium sensor in the sodium channel modulates cardiac excitability

21 March 2017

1 reference

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Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel

21 March 2017

1 reference

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TRPV1 structures in distinct conformations reveal activation mechanisms

21 March 2017

1 reference

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Structure of the TRPV1 ion channel determined by electron cryo-microscopy

21 March 2017

1 reference

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Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

21 March 2017

1 reference

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Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

21 March 2017

1 reference

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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

21 March 2017

1 reference

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Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

21 March 2017

1 reference

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Crystallographic basis for calcium regulation of sodium channels

21 March 2017

1 reference

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The crystal structure of a voltage-gated sodium channel

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

BIN1 localizes the L-type calcium channel to cardiac T-tubules

21 March 2017

1 reference

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Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA

21 March 2017

1 reference

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Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel

21 March 2017

1 reference

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Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts

21 March 2017

1 reference

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Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias

21 March 2017

1 reference

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International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

21 March 2017

1 reference

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Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

21 March 2017

1 reference

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Binding of [3H]batrachotoxinin A benzoate to specific sites on rat cardiac sodium channels

21 March 2017

1 reference

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Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes

21 March 2017

1 reference

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A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice

21 March 2017

1 reference

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Structure and function of voltage-gated sodium channels at atomic resolution

21 March 2017

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Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle

7 April 2017

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A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.

28 September 2017

1 reference

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A micropatterning approach for imaging dynamic Cx43 trafficking to cell-cell borders

28 September 2017

1 reference

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Autoregulation of connexin43 gap junction formation by internally translated isoforms

28 September 2017

1 reference

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Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart

28 September 2017

1 reference

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Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations

28 September 2017

1 reference

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Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry

28 September 2017

1 reference

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Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.

28 September 2017

1 reference

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Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.

28 September 2017

1 reference

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Fibroblast growth factor homologous factors modulate cardiac calcium channels

28 September 2017

1 reference

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The arrhythmogenic consequences of increasing late INa in the cardiomyocyte

28 September 2017

1 reference

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Distribution and function of sodium channel subtypes in human atrial myocardium

28 September 2017

1 reference

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Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels

28 September 2017

1 reference

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An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations

28 September 2017

1 reference

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Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model

28 September 2017

1 reference

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Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7) [corrected]

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic

28 September 2017

1 reference

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Tracking a complete voltage-sensor cycle with metal-ion bridges

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane.

28 September 2017

1 reference

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Pathophysiology of the cardiac late Na current and its potential as a drug target

28 September 2017

1 reference

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Structural basis for gating charge movement in the voltage sensor of a sodium channel

28 September 2017

1 reference

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BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

28 September 2017

1 reference

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The perinexus: a new feature of Cx43 gap junction organization.

28 September 2017

1 reference

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Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons.

28 September 2017

1 reference

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Post-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

CaMKII in myocardial hypertrophy and heart failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Sequential dissection of multiple ionic currents in single cardiac myocytes under action potential-clamp

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Ankyrin-based cellular pathways for cardiac ion channel and transporter targeting and regulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

CaMKII regulation of voltage-gated sodium channels and cell excitability

28 September 2017

1 reference

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Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Targeting voltage sensors in sodium channels with spider toxins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

A colorful explanation for atrial arrhythmias

28 September 2017

1 reference

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Ca/calmodulin kinase II differentially modulates potassium currents

28 September 2017

1 reference

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Calcium/calmodulin-dependent kinase II regulation of cardiac ion channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

CaMKII and its role in cardiac arrhythmia

28 September 2017

1 reference

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Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Pathophysiology and pharmacology of the cardiac "late sodium current.".

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Late sodium current in failing heart: friend or foe?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Voltage-gated ion channels and gating modifier toxins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Neurotrophin B receptor kinase increases Kv subfamily member 1.3 (Kv1.3) ion channel half-life and surface expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Calcium-dependent regulation of the voltage-gated sodium channel hH1: intrinsic and extrinsic sensors use a common molecular switch

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Molecular physiology of cardiac repolarization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Rapid turnover of the "functional" Na(+)-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Calmodulin signaling via the IQ motif

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Molecular mechanism for an inherited cardiac arrhythmia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Roles of a membrane-localized beta subunit in the formation and targeting of functional L-type Ca2+ channels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Mechanism of voltage gating in potassium channels

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4376415

Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.

31 May 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Distinct subcellular localization of different sodium channel alpha and beta subunits in single ventricular myocytes from mouse heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2014.281428

Gating of the late Na+ channel in normal and failing human myocardium

21 January 2018

1 reference

12 December 2020

Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channel

1 reference

12 December 2020

Inherited Brugada and long QT-3 syndrome mutations of a single residue of the cardiac sodium channel confer distinct channel and clinical phenotypes

1 reference

12 December 2020

Rapid turnover of connexin43 in the adult rat heart

1 reference

12 December 2020

A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias

1 reference

12 December 2020

10.1113/JPHYSIOL.2014.281428

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25772290%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25772290%20AND%20SRC:MED&resulttype=core&format=json