Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. (Q44072116)

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English	Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.	scientific article

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11 November 2019

Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block (English)

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11 November 2019

transmembrane protein

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Vladimir Yarov-Yarovoy

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11 November 2019

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Jancy C McPhee

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11 November 2019

Diane Idsvoog

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11 November 2019

Caroline Pate

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11 November 2019

Todd Scheuer

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11 November 2019

William A Catterall

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11 November 2019

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18 July 2002

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11 November 2019

Journal of Biological Chemistry

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11 November 2019

277

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11 November 2019

38

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11 November 2019

35393-35401

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11 November 2019

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

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21 January 2018

Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms

1 reference

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21 January 2018

Structure and function of voltage-gated sodium channels

1 reference

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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

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Sodium channels and gating currents

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Molecular model of the action potential sodium channel

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Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains

1 reference

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21 January 2018

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

1 reference

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21 January 2018

Molecular basis of charge movement in voltage-gated sodium channels

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Inhibition of inactivation of single sodium channels by a site-directed antibody

1 reference

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A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

1 reference

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21 January 2018

A mutation in segment IVS6 disrupts fast inactivation of sodium channels

1 reference

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21 January 2018

Interaction between the sodium channel inactivation linker and domain III S4-S5.

1 reference

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21 January 2018

Role in fast inactivation of the IV/S4-S5 loop of the human muscle Na+ channel probed by cysteine mutagenesis

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21 January 2018

Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel

1 reference

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21 January 2018

A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation

1 reference

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21 January 2018

Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel

1 reference

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21 January 2018

A unique role for the S4 segment of domain 4 in the inactivation of sodium channels

1 reference

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21 January 2018

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit

1 reference

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21 January 2018

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Nomenclature of voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel

1 reference

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21 January 2018

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels

1 reference

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Differential interaction of R-mexiletine with the local anesthetic receptor site on brain and heart sodium channel alpha-subunits.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL.

1 reference

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21 January 2018

Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Local anesthetic block of batrachotoxin-resistant muscle Na+ channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Multiple sequence alignment with Clustal X

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.

1 reference

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21 January 2018

Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

The anatomy and taxonomy of protein structure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

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Structural basis of amino acid alpha helix propensity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

21 January 2018

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

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Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M206126200

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State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels

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Electrophysiology of sipatrigine: a lamotrigine derivative exhibiting neuroprotective effects.

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BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

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A mutation in segment I-S6 alters slow inactivation of sodium channels

1 reference

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The open pore conformation of potassium channels

1 reference

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Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy

1 reference

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The activation gate of a voltage-gated K+ channel can be trapped in the open state by an intersubunit metal bridge

1 reference

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Structural rearrangements underlying K+-channel activation gating

1 reference

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Structure of the KcsA channel intracellular gate in the open state

1 reference

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Inactivation of the sodium channel. II. Gating current experiments

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Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle

1 reference

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Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.

1 reference

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Conformational pathways in the gating of Escherichia coli mechanosensitive channel

1 reference

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Structural parts involved in activation and inactivation of the sodium channel

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10.1074/JBC.M206126200

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12130650%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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