The glutamatergic system as a target for neuropathic pain relief (Q27006077)

language of work or name

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February 2013

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published in

Experimental Physiology

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volume

98

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issue

2

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page(s)

372-84

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Glutamate immunocytochemistry in the dorsal horn after injury or stimulation of the sciatic nerve of rats.

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Peripheral neuropathic pain: from mechanisms to symptoms

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Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model

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Glutamate receptors and pain

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Peripheral excitatory amino acids

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Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats

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The beta-lactam antibiotic, ceftriaxone, inhibits the development of opioid-induced hyperalgesia in mice

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The role of neuroinflammation and neuroimmune activation in persistent pain

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Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats

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Neuropathic pain: what do we do with all these theories?

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Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats

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Up-regulation of metabotropic glutamate receptor subtypes 3 and 5 in spinal cord in a clinical model of persistent inflammation and hyperalgesia

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Neuroscience: Unbearable lightness of touch

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Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia

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Glutamate receptors and nociception: implications for the drug treatment of pain

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Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats

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Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn.

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Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons.

21 January 2018

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Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.

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EAAT expression by macrophages and microglia: still more questions than answers

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Microglia as a source and target of cytokines

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Cloned glutamate receptors

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Translation of symptoms and signs into mechanisms in neuropathic pain

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Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects

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Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.

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Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics

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Ionotropic and metabotropic glutamate receptor structure and pharmacology

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Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice

21 January 2018

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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

21 January 2018

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Impairment of VGLUT2 but not VGLUT1 signaling reduces neuropathy-induced hypersensitivity

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Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.

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Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?

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Sequence and expression of a metabotropic glutamate receptor

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The development of morphine tolerance and dependence is associated with translocation of protein kinase C.

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Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain

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Role of group II and group III metabotropic glutamate receptors in spinal cord injury

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A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo

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The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine

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Vesicular glutamate transporter acts as a metabolic regulator

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Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex

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Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouse

21 January 2018

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Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception

21 January 2018

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Metabotropic glutamate receptors: novel targets for pain relief

21 January 2018

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Peripheral metabotropic glutamate receptors as drug targets for pain relief

21 January 2018

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Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain

21 January 2018

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Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain

21 January 2018

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The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.

21 January 2018

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Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons

21 January 2018

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The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations

21 January 2018

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Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus.

21 January 2018

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The metabotropic glutamate receptors: structure and functions

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Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors

21 January 2018

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Spinal opioid mu receptor expression in lumbar spinal cord of rats following nerve injury

21 January 2018

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Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model

21 January 2018

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Glutamate release in severe brain ischaemia is mainly by reversed uptake.

21 January 2018

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo

21 January 2018

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Quality improvement of painful peripheral neuropathy

21 January 2018

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Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones

21 January 2018

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Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

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II. Glutamine and glutamate

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Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection

21 January 2018

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Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up-regulated in Alzheimer's disease.

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Glutamatergic mechanisms in different disease states: overview and therapeutical implications -- an introduction

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Role of metabotropic glutamate receptor subtype 5 (mGluR5) in the maintenance of cold hypersensitivity following a peripheral mononeuropathy in the rat.

21 January 2018

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Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.

21 January 2018

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mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia.

21 January 2018

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Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance

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Glial glutamate transporter 1 regulates the spatial and temporal coding of glutamatergic synaptic transmission in spinal lamina II neurons

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Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model

21 January 2018

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Intrathecal ultra-low dose naloxone enhances the antinociceptive effect of morphine by enhancing the reuptake of excitatory amino acids from the synaptic cleft in the spinal cord of partial sciatic nerve-transected rats.

21 January 2018

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mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

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Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy

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Metabotropic glutamate 1alpha receptors on peripheral primary afferent fibers: their role in nociception

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Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities

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Glutamate‐mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes

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Role of Group I Metabotropic Glutamate Receptors in Traumatic Spinal Cord White Matter Injury

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ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

21 January 2018

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https://api.crossref.org/works/10.1113%2FEXPPHYSIOL.2012.069922

10.1113/EXPPHYSIOL.2012.069922

21 January 2018

Identifiers

DOI

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PubMed publication ID

23002244

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